2P50

Crystal structure of N-acetyl-D-Glucosamine-6-Phosphate deacetylase liganded with Zn

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006040	biological_process	amino sugar metabolic process
A	0006044	biological_process	N-acetylglucosamine metabolic process
A	0006046	biological_process	N-acetylglucosamine catabolic process
A	0008270	molecular_function	zinc ion binding
A	0008448	molecular_function	N-acetylglucosamine-6-phosphate deacetylase activity
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0019262	biological_process	N-acetylneuraminate catabolic process
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0047419	molecular_function	N-acetylgalactosamine-6-phosphate deacetylase activity
A	0051289	biological_process	protein homotetramerization
B	0006040	biological_process	amino sugar metabolic process
B	0006044	biological_process	N-acetylglucosamine metabolic process
B	0006046	biological_process	N-acetylglucosamine catabolic process
B	0008270	molecular_function	zinc ion binding
B	0008448	molecular_function	N-acetylglucosamine-6-phosphate deacetylase activity
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0019262	biological_process	N-acetylneuraminate catabolic process
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0047419	molecular_function	N-acetylgalactosamine-6-phosphate deacetylase activity
B	0051289	biological_process	protein homotetramerization
C	0006040	biological_process	amino sugar metabolic process
C	0006044	biological_process	N-acetylglucosamine metabolic process
C	0006046	biological_process	N-acetylglucosamine catabolic process
C	0008270	molecular_function	zinc ion binding
C	0008448	molecular_function	N-acetylglucosamine-6-phosphate deacetylase activity
C	0016787	molecular_function	hydrolase activity
C	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C	0019262	biological_process	N-acetylneuraminate catabolic process
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0047419	molecular_function	N-acetylgalactosamine-6-phosphate deacetylase activity
C	0051289	biological_process	protein homotetramerization
D	0006040	biological_process	amino sugar metabolic process
D	0006044	biological_process	N-acetylglucosamine metabolic process
D	0006046	biological_process	N-acetylglucosamine catabolic process
D	0008270	molecular_function	zinc ion binding
D	0008448	molecular_function	N-acetylglucosamine-6-phosphate deacetylase activity
D	0016787	molecular_function	hydrolase activity
D	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D	0019262	biological_process	N-acetylneuraminate catabolic process
D	0032991	cellular_component	protein-containing complex
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0047419	molecular_function	N-acetylgalactosamine-6-phosphate deacetylase activity
D	0051289	biological_process	protein homotetramerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	GLU131
A	HIS195
A	HIS216
A	HOH690

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 601

Chain	Residue
B	GLU131
B	HIS195
B	HIS216
B	HOH696

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 601

Chain	Residue
C	HIS195
C	HIS216
C	HOH688
C	GLU131

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 601

Chain	Residue
D	GLU131
D	HIS195
D	HIS216
D	HOH679

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:17567048

Chain	Residue	Details
A	ASP273
B	ASP273
C	ASP273
D	ASP273

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site_id	SWS_FT_FI2
Number of Residues	32
Details	BINDING: BINDING => ECO:0000269|PubMed:17567048

Chain	Residue	Details
A	GLU131
B	THR142
B	HIS195
B	HIS216
B	ASN219
B	ARG227
B	ASP248
B	LEU306
C	GLU131
C	THR142
C	HIS195
A	THR142
C	HIS216
C	ASN219
C	ARG227
C	ASP248
C	LEU306
D	GLU131
D	THR142
D	HIS195
D	HIS216
D	ASN219
A	HIS195
D	ARG227
D	ASP248
D	LEU306
A	HIS216
A	ASN219
A	ARG227
A	ASP248
A	LEU306
B	GLU131

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