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2P41

Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppG2'OMe and S-Adenosyl-L-homocysteine

Functional Information from GO Data
ChainGOidnamespacecontents
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
A0004483molecular_functionmRNA (nucleoside-2'-O-)-methyltransferase activity
A0005524molecular_functionATP binding
A0008168molecular_functionmethyltransferase activity
A0032259biological_processmethylation
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1002
ChainResidue
AHIS110
AGLU111
ASAH1012
AHOH1202
AHOH1220
AHOH1229

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 1003
ChainResidue
AHOH1039
AHOH1082
AHOH1251
ALYS105
AHIS110
ASAH1012

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 1004
ChainResidue
AGLN34
AGLU49
AHIS52
AHIS53
ATRP64
AARG68
AHOH1254
AHOH1282
AHOH1283

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 1005
ChainResidue
ALYS105
AHIS110
ASER150
ASER151
AARG160
AHOH1073
AHOH1228
AHOH1233
AHOH1251

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 1006
ChainResidue
ALYS29
AARG57
AARG212
ASO41008
AHOH1144
AHOH1145
AHOH1246

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1007
ChainResidue
AARG38
ALYS42
ASER56
AARG57
AARG84
AHOH1153
AHOH1247
AHOH1284

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 1008
ChainResidue
AARG57
ALYS61
ASO41006
AHOH1118
AHOH1142
AHOH1246
AHOH1306

site_idAC8
Number of Residues20
DetailsBINDING SITE FOR RESIDUE G1G A 1001
ChainResidue
ALYS14
ALEU17
AASN18
ALEU20
ALYS22
APHE25
ALYS29
APRO108
AGLY109
ASER150
ASER151
APRO152
ASER214
AHOH1018
AHOH1035
AHOH1073
AHOH1107
AHOH1138
AHOH1144
AHOH1200

site_idAC9
Number of Residues21
DetailsBINDING SITE FOR RESIDUE SAH A 1012
ChainResidue
ASER56
AGLY58
AGLY81
ACYS82
AGLY86
ATRP87
ATHR104
ALYS105
AHIS110
AVAL130
AASP131
AVAL132
APHE133
AASP146
ASO41002
ASO41003
ACIT1013
AHOH1028
AHOH1031
AHOH1038
AHOH1082

site_idBC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE CIT A 1013
ChainResidue
AARG163
AARG163
ASAH1012
AHOH1065
AHOH1082
AHOH1089
AHOH1163
ALYS105
AASP131
APHE134
AVAL156
AGLY159
AARG160

site_idBC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 1009
ChainResidue
ALYS30
AARG57
AARG212

site_idBC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 1010
ChainResidue
AGLU49
ATHR50
AASP51
AGLU67
AARG68
AHOH1282

site_idBC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 1011
ChainResidue
AGLU11
ALYS14
ASER15
AASN18
APRO152
APRO154
AHOH1111
AHOH1218
AHOH1294

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PDB entries from 2024-10-30

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