Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0004483 | molecular_function | methyltransferase cap1 activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1002 |
| Chain | Residue |
| A | HIS110 |
| A | GLU111 |
| A | SAH1012 |
| A | HOH1202 |
| A | HOH1220 |
| A | HOH1229 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1003 |
| Chain | Residue |
| A | HOH1039 |
| A | HOH1082 |
| A | HOH1251 |
| A | LYS105 |
| A | HIS110 |
| A | SAH1012 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1004 |
| Chain | Residue |
| A | GLN34 |
| A | GLU49 |
| A | HIS52 |
| A | HIS53 |
| A | TRP64 |
| A | ARG68 |
| A | HOH1254 |
| A | HOH1282 |
| A | HOH1283 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1005 |
| Chain | Residue |
| A | LYS105 |
| A | HIS110 |
| A | SER150 |
| A | SER151 |
| A | ARG160 |
| A | HOH1073 |
| A | HOH1228 |
| A | HOH1233 |
| A | HOH1251 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1006 |
| Chain | Residue |
| A | LYS29 |
| A | ARG57 |
| A | ARG212 |
| A | SO41008 |
| A | HOH1144 |
| A | HOH1145 |
| A | HOH1246 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1007 |
| Chain | Residue |
| A | ARG38 |
| A | LYS42 |
| A | SER56 |
| A | ARG57 |
| A | ARG84 |
| A | HOH1153 |
| A | HOH1247 |
| A | HOH1284 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1008 |
| Chain | Residue |
| A | ARG57 |
| A | LYS61 |
| A | SO41006 |
| A | HOH1118 |
| A | HOH1142 |
| A | HOH1246 |
| A | HOH1306 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE G1G A 1001 |
| Chain | Residue |
| A | LYS14 |
| A | LEU17 |
| A | ASN18 |
| A | LEU20 |
| A | LYS22 |
| A | PHE25 |
| A | LYS29 |
| A | PRO108 |
| A | GLY109 |
| A | SER150 |
| A | SER151 |
| A | PRO152 |
| A | SER214 |
| A | HOH1018 |
| A | HOH1035 |
| A | HOH1073 |
| A | HOH1107 |
| A | HOH1138 |
| A | HOH1144 |
| A | HOH1200 |
| site_id | AC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAH A 1012 |
| Chain | Residue |
| A | SER56 |
| A | GLY58 |
| A | GLY81 |
| A | CYS82 |
| A | GLY86 |
| A | TRP87 |
| A | THR104 |
| A | LYS105 |
| A | HIS110 |
| A | VAL130 |
| A | ASP131 |
| A | VAL132 |
| A | PHE133 |
| A | ASP146 |
| A | SO41002 |
| A | SO41003 |
| A | CIT1013 |
| A | HOH1028 |
| A | HOH1031 |
| A | HOH1038 |
| A | HOH1082 |
| site_id | BC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CIT A 1013 |
| Chain | Residue |
| A | ARG163 |
| A | ARG163 |
| A | SAH1012 |
| A | HOH1065 |
| A | HOH1082 |
| A | HOH1089 |
| A | HOH1163 |
| A | LYS105 |
| A | ASP131 |
| A | PHE134 |
| A | VAL156 |
| A | GLY159 |
| A | ARG160 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1009 |
| Chain | Residue |
| A | LYS30 |
| A | ARG57 |
| A | ARG212 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1010 |
| Chain | Residue |
| A | GLU49 |
| A | THR50 |
| A | ASP51 |
| A | GLU67 |
| A | ARG68 |
| A | HOH1282 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1011 |
| Chain | Residue |
| A | GLU11 |
| A | LYS14 |
| A | SER15 |
| A | ASN18 |
| A | PRO152 |
| A | PRO154 |
| A | HOH1111 |
| A | HOH1218 |
| A | HOH1294 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Region: {"description":"Interaction with host SCRIB","evidences":[{"source":"UniProtKB","id":"Q01299","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Motif: {"description":"SUMO-interacting motif","evidences":[{"source":"UniProtKB","id":"P29990","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For 2'-O-MTase activity","evidences":[{"source":"UniProtKB","id":"Q6YMS4","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12032088","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P1D","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 7 |
| Details | Site: {"description":"mRNA cap binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Site: {"description":"mRNA cap binding; via carbonyl oxygen","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Site: {"description":"Essential for 2'-O-methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Site: {"description":"Essential for 2'-O-methyltransferase and N-7 methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P03314","evidenceCode":"ECO:0000250"}]} |
