2P3O

Crystal Structure of Dengue Methyltransferase in Complex with 7MeGpppA and S-Adenosyl-L-homocysteine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0004483	molecular_function	methyltransferase cap1 activity
A	0005524	molecular_function	ATP binding
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1002

Chain	Residue
A	GLN34
A	HIS52
A	TRP64
A	ARG68
A	ARG246

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1003

Chain	Residue
A	ARG84
A	ARG38
A	LYS42
A	SER56
A	ARG57

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1004

Chain	Residue
A	LYS105
A	HIS110
A	SER150
A	SER151
A	ARG160

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1005

Chain	Residue
A	HIS110
A	GLU149
A	SAH1001

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1006

Chain	Residue
A	GLY109
A	HIS110
A	GLU111
A	SAH1001

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1007

Chain	Residue
A	VAL229
A	SER230
A	ASN233
A	ARG237

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1008

Chain	Residue
A	LYS29
A	ARG57
A	ARG212
A	HOH1019

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1009

Chain	Residue
A	GLU138
A	ARG139
A	HOH1018

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1010

Chain	Residue
A	LYS30
A	ARG212

---

site_id	BC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAH A 1001

Chain	Residue
A	SER56
A	GLY58
A	GLY81
A	GLY86
A	TRP87
A	THR104
A	LYS105
A	HIS110
A	VAL130
A	ASP131
A	VAL132
A	PHE133
A	ASP146
A	SO41005
A	SO41006
A	CIT1011
A	HOH1035
A	HOH1038

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT A 1011

Chain	Residue
A	LYS105
A	ASP131
A	PHE133
A	PHE134
A	GLY159
A	ARG160
A	ARG163
A	ARG163
A	SAH1001

---

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GTA A 1012

Chain	Residue
A	LYS14
A	LEU17
A	ASN18
A	LEU20
A	PHE25
A	LYS29
A	PRO108
A	SER150
A	SER151
A	PRO152

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Region: {"description":"Interaction with host SCRIB","evidences":[{"source":"UniProtKB","id":"Q01299","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Motif: {"description":"SUMO-interacting motif","evidences":[{"source":"UniProtKB","id":"P29990","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"For 2'-O-MTase activity","evidences":[{"source":"UniProtKB","id":"Q6YMS4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12032088","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P1D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	7
Details	Site: {"description":"mRNA cap binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"mRNA cap binding; via carbonyl oxygen","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Site: {"description":"Essential for 2'-O-methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Site: {"description":"Essential for 2'-O-methyltransferase and N-7 methyltransferase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00924","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P03314","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---