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2P2L

Rac1-GDP-Zinc Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001764biological_processneuron migration
A0001934biological_processpositive regulation of protein phosphorylation
A0003376biological_processsphingosine-1-phosphate receptor signaling pathway
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005802cellular_componenttrans-Golgi network
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006954biological_processinflammatory response
A0007015biological_processactin filament organization
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007163biological_processestablishment or maintenance of cell polarity
A0007264biological_processsmall GTPase-mediated signal transduction
A0008045biological_processmotor neuron axon guidance
A0008360biological_processregulation of cell shape
A0008361biological_processregulation of cell size
A0009611biological_processresponse to wounding
A0009653biological_processanatomical structure morphogenesis
A0010310biological_processregulation of hydrogen peroxide metabolic process
A0010591biological_processregulation of lamellipodium assembly
A0010592biological_processpositive regulation of lamellipodium assembly
A0010595biological_processpositive regulation of endothelial cell migration
A0010764biological_processnegative regulation of fibroblast migration
A0010811biological_processpositive regulation of cell-substrate adhesion
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0016601biological_processRac protein signal transduction
A0016787molecular_functionhydrolase activity
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0030027cellular_componentlamellipodium
A0030031biological_processcell projection assembly
A0030032biological_processlamellipodium assembly
A0030036biological_processactin cytoskeleton organization
A0030041biological_processactin filament polymerization
A0030334biological_processregulation of cell migration
A0030425cellular_componentdendrite
A0030667cellular_componentsecretory granule membrane
A0030865biological_processcortical cytoskeleton organization
A0031116biological_processpositive regulation of microtubule polymerization
A0031410cellular_componentcytoplasmic vesicle
A0031529biological_processruffle organization
A0031996molecular_functionthioesterase binding
A0032587cellular_componentruffle membrane
A0032707biological_processnegative regulation of interleukin-23 production
A0032956biological_processregulation of actin cytoskeleton organization
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0035025biological_processpositive regulation of Rho protein signal transduction
A0035556biological_processintracellular signal transduction
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0042470cellular_componentmelanosome
A0042995cellular_componentcell projection
A0043020cellular_componentNADPH oxidase complex
A0043197cellular_componentdendritic spine
A0043652biological_processengulfment of apoptotic cell
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045428biological_processregulation of nitric oxide biosynthetic process
A0045730biological_processrespiratory burst
A0048012biological_processhepatocyte growth factor receptor signaling pathway
A0048261biological_processnegative regulation of receptor-mediated endocytosis
A0048870biological_processcell motility
A0051022molecular_functionRho GDP-dissociation inhibitor binding
A0051492biological_processregulation of stress fiber assembly
A0051496biological_processpositive regulation of stress fiber assembly
A0051668biological_processlocalization within membrane
A0051894biological_processpositive regulation of focal adhesion assembly
A0055038cellular_componentrecycling endosome membrane
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060263biological_processregulation of respiratory burst
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0071526biological_processsemaphorin-plexin signaling pathway
A0090023biological_processpositive regulation of neutrophil chemotaxis
A0097178biological_processruffle assembly
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0101003cellular_componentficolin-1-rich granule membrane
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1902622biological_processregulation of neutrophil migration
B0001764biological_processneuron migration
B0001934biological_processpositive regulation of protein phosphorylation
B0003376biological_processsphingosine-1-phosphate receptor signaling pathway
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005802cellular_componenttrans-Golgi network
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0006954biological_processinflammatory response
B0007015biological_processactin filament organization
B0007155biological_processcell adhesion
B0007160biological_processcell-matrix adhesion
B0007163biological_processestablishment or maintenance of cell polarity
B0007264biological_processsmall GTPase-mediated signal transduction
B0008045biological_processmotor neuron axon guidance
B0008360biological_processregulation of cell shape
B0008361biological_processregulation of cell size
B0009611biological_processresponse to wounding
B0009653biological_processanatomical structure morphogenesis
B0010310biological_processregulation of hydrogen peroxide metabolic process
B0010591biological_processregulation of lamellipodium assembly
B0010592biological_processpositive regulation of lamellipodium assembly
B0010595biological_processpositive regulation of endothelial cell migration
B0010764biological_processnegative regulation of fibroblast migration
B0010811biological_processpositive regulation of cell-substrate adhesion
B0016020cellular_componentmembrane
B0016477biological_processcell migration
B0016601biological_processRac protein signal transduction
B0016787molecular_functionhydrolase activity
B0019899molecular_functionenzyme binding
B0019901molecular_functionprotein kinase binding
B0030027cellular_componentlamellipodium
B0030031biological_processcell projection assembly
B0030032biological_processlamellipodium assembly
B0030036biological_processactin cytoskeleton organization
B0030041biological_processactin filament polymerization
B0030334biological_processregulation of cell migration
B0030425cellular_componentdendrite
B0030667cellular_componentsecretory granule membrane
B0030865biological_processcortical cytoskeleton organization
B0031116biological_processpositive regulation of microtubule polymerization
B0031410cellular_componentcytoplasmic vesicle
B0031529biological_processruffle organization
B0031996molecular_functionthioesterase binding
B0032587cellular_componentruffle membrane
B0032707biological_processnegative regulation of interleukin-23 production
B0032956biological_processregulation of actin cytoskeleton organization
B0034446biological_processsubstrate adhesion-dependent cell spreading
B0035025biological_processpositive regulation of Rho protein signal transduction
B0035556biological_processintracellular signal transduction
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0042470cellular_componentmelanosome
B0042995cellular_componentcell projection
B0043020cellular_componentNADPH oxidase complex
B0043197cellular_componentdendritic spine
B0043652biological_processengulfment of apoptotic cell
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0045428biological_processregulation of nitric oxide biosynthetic process
B0045730biological_processrespiratory burst
B0048012biological_processhepatocyte growth factor receptor signaling pathway
B0048261biological_processnegative regulation of receptor-mediated endocytosis
B0048870biological_processcell motility
B0051022molecular_functionRho GDP-dissociation inhibitor binding
B0051492biological_processregulation of stress fiber assembly
B0051496biological_processpositive regulation of stress fiber assembly
B0051668biological_processlocalization within membrane
B0051894biological_processpositive regulation of focal adhesion assembly
B0055038cellular_componentrecycling endosome membrane
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060263biological_processregulation of respiratory burst
B0060326biological_processcell chemotaxis
B0070062cellular_componentextracellular exosome
B0071526biological_processsemaphorin-plexin signaling pathway
B0090023biological_processpositive regulation of neutrophil chemotaxis
B0097178biological_processruffle assembly
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0101003cellular_componentficolin-1-rich granule membrane
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B1902622biological_processregulation of neutrophil migration
C0001764biological_processneuron migration
C0001934biological_processpositive regulation of protein phosphorylation
C0003376biological_processsphingosine-1-phosphate receptor signaling pathway
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005802cellular_componenttrans-Golgi network
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006954biological_processinflammatory response
C0007015biological_processactin filament organization
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007163biological_processestablishment or maintenance of cell polarity
C0007264biological_processsmall GTPase-mediated signal transduction
C0008045biological_processmotor neuron axon guidance
C0008360biological_processregulation of cell shape
C0008361biological_processregulation of cell size
C0009611biological_processresponse to wounding
C0009653biological_processanatomical structure morphogenesis
C0010310biological_processregulation of hydrogen peroxide metabolic process
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0010595biological_processpositive regulation of endothelial cell migration
C0010764biological_processnegative regulation of fibroblast migration
C0010811biological_processpositive regulation of cell-substrate adhesion
C0016020cellular_componentmembrane
C0016477biological_processcell migration
C0016601biological_processRac protein signal transduction
C0016787molecular_functionhydrolase activity
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0030027cellular_componentlamellipodium
C0030031biological_processcell projection assembly
C0030032biological_processlamellipodium assembly
C0030036biological_processactin cytoskeleton organization
C0030041biological_processactin filament polymerization
C0030334biological_processregulation of cell migration
C0030425cellular_componentdendrite
C0030667cellular_componentsecretory granule membrane
C0030865biological_processcortical cytoskeleton organization
C0031116biological_processpositive regulation of microtubule polymerization
C0031410cellular_componentcytoplasmic vesicle
C0031529biological_processruffle organization
C0031996molecular_functionthioesterase binding
C0032587cellular_componentruffle membrane
C0032707biological_processnegative regulation of interleukin-23 production
C0032956biological_processregulation of actin cytoskeleton organization
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035025biological_processpositive regulation of Rho protein signal transduction
C0035556biological_processintracellular signal transduction
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042470cellular_componentmelanosome
C0042995cellular_componentcell projection
C0043020cellular_componentNADPH oxidase complex
C0043197cellular_componentdendritic spine
C0043652biological_processengulfment of apoptotic cell
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045428biological_processregulation of nitric oxide biosynthetic process
C0045730biological_processrespiratory burst
C0048012biological_processhepatocyte growth factor receptor signaling pathway
C0048261biological_processnegative regulation of receptor-mediated endocytosis
C0048870biological_processcell motility
C0051022molecular_functionRho GDP-dissociation inhibitor binding
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051668biological_processlocalization within membrane
C0051894biological_processpositive regulation of focal adhesion assembly
C0055038cellular_componentrecycling endosome membrane
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060263biological_processregulation of respiratory burst
C0060326biological_processcell chemotaxis
C0070062cellular_componentextracellular exosome
C0071526biological_processsemaphorin-plexin signaling pathway
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0097178biological_processruffle assembly
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0101003cellular_componentficolin-1-rich granule membrane
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1902622biological_processregulation of neutrophil migration
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN A 201
ChainResidue
ATHR17
ATHR35
AGDP200
AHOH915
AHOH1114
AHOH1148

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 202
ChainResidue
AHIS104
AASP63
AGLU100
AHIS103

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN B 201
ChainResidue
BTHR17
BTHR35
BGDP200
BHOH412
BHOH421
BHOH431

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 202
ChainResidue
BASP63
BGLU100
BHIS104
CHIS103

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN C 201
ChainResidue
CTHR17
CTHR35
CGDP200
CHOH424
CHOH434
CHOH443

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 202
ChainResidue
BHIS103
CASP63
CGLU100
CHIS104

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 901
ChainResidue
AASP38
AHOH1125
BASP38
CASP38

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 902
ChainResidue
AGLU127
AGLU131
CGLU127
CGLU131

site_idAC9
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GDP A 200
ChainResidue
AALA13
AVAL14
AGLY15
ALYS16
ATHR17
ACYS18
APHE28
AILE33
ALYS116
AASP118
ALEU119
ASER158
AALA159
ALEU160
AZN201
AHOH908
AHOH915
AHOH929
AHOH965
AHOH977
AHOH1024
AHOH1030
AHOH1073
AHOH1114
AHOH1148

site_idBC1
Number of Residues28
DetailsBINDING SITE FOR RESIDUE GDP B 200
ChainResidue
AASN43
BASP11
BALA13
BVAL14
BGLY15
BLYS16
BTHR17
BCYS18
BPHE28
BILE33
BLYS116
BASP118
BLEU119
BSER158
BALA159
BLEU160
BZN201
BHOH204
BHOH207
BHOH222
BHOH239
BHOH282
BHOH333
BHOH343
BHOH412
BHOH421
BHOH431
BHOH453

site_idBC2
Number of Residues27
DetailsBINDING SITE FOR RESIDUE GDP C 200
ChainResidue
CILE33
CLYS116
CASP118
CLEU119
CSER158
CALA159
CLEU160
CZN201
CHOH204
CHOH209
CHOH228
CHOH270
CHOH303
CHOH330
CHOH337
CHOH354
CHOH424
CHOH434
CHOH443
BASN43
CALA13
CVAL14
CGLY15
CLYS16
CTHR17
CCYS18
CPHE28

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR
ChainResidueDetails
AALA13
AGLY30
AGLY60
BALA13
BGLY30
BGLY60
CALA13
CGLY30
CGLY60

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:5HZH
ChainResidueDetails
ALYS116
AALA159
BLYS116
BALA159
CLYS116
CALA159

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
ATYR32
BTYR32
CTYR32

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
ATHR35
BTHR35
CTHR35

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617634
ChainResidueDetails
ASER71
BSER71
CSER71

site_idSWS_FT_FI6
Number of Residues6
DetailsLIPID: (Microbial infection) N6-palmitoyl lysine => ECO:0000269|PubMed:29074776
ChainResidueDetails
ALYS183
ALYS184
BLYS183
BLYS184
CLYS183
CLYS184

site_idSWS_FT_FI7
Number of Residues3
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR32
BTYR32
CTYR32

site_idSWS_FT_FI8
Number of Residues3
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ATHR35
BTHR35
CTHR35

site_idSWS_FT_FI9
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184
ChainResidueDetails
ALYS147
BLYS147
CLYS147

site_idSWS_FT_FI10
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198
ChainResidueDetails
ALYS166
BLYS166
CLYS166

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN61

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLN61

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CGLN61

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AALA13

site_idCSA5
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BALA13

site_idCSA6
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CALA13

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PDB entries from 2024-07-17

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