2P2G
Crystal Structure of Ornithine Carbamoyltransferase from Mycobacterium Tuberculosis (Rv1656): Orthorhombic Form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006526 | biological_process | L-arginine biosynthetic process |
| A | 0006591 | biological_process | ornithine metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0019240 | biological_process | citrulline biosynthetic process |
| A | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| B | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006526 | biological_process | L-arginine biosynthetic process |
| B | 0006591 | biological_process | ornithine metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0019240 | biological_process | citrulline biosynthetic process |
| B | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| C | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006526 | biological_process | L-arginine biosynthetic process |
| C | 0006591 | biological_process | ornithine metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0019240 | biological_process | citrulline biosynthetic process |
| C | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| D | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0006526 | biological_process | L-arginine biosynthetic process |
| D | 0006591 | biological_process | ornithine metabolic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0016597 | molecular_function | amino acid binding |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| D | 0019240 | biological_process | citrulline biosynthetic process |
| D | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| E | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006520 | biological_process | amino acid metabolic process |
| E | 0006526 | biological_process | L-arginine biosynthetic process |
| E | 0006591 | biological_process | ornithine metabolic process |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0016597 | molecular_function | amino acid binding |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| E | 0019240 | biological_process | citrulline biosynthetic process |
| E | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| F | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006520 | biological_process | amino acid metabolic process |
| F | 0006526 | biological_process | L-arginine biosynthetic process |
| F | 0006591 | biological_process | ornithine metabolic process |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0016597 | molecular_function | amino acid binding |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| F | 0019240 | biological_process | citrulline biosynthetic process |
| F | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 800 |
| Chain | Residue |
| A | SER50 |
| A | THR51 |
| A | ARG52 |
| A | PRO266 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 801 |
| Chain | Residue |
| A | ASN248 |
| A | SER249 |
| A | THR274 |
| A | ALA276 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 800 |
| Chain | Residue |
| B | THR51 |
| B | ARG52 |
| C | HOH818 |
| B | SER50 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 801 |
| Chain | Residue |
| B | ASN248 |
| B | SER249 |
| B | THR274 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 802 |
| Chain | Residue |
| A | ASP72 |
| A | GLY74 |
| B | ASP72 |
| B | GLY74 |
| C | ASP72 |
| C | GLY74 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 803 |
| Chain | Residue |
| A | ARG54 |
| A | ASP72 |
| B | ARG54 |
| C | ARG54 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 800 |
| Chain | Residue |
| C | SER50 |
| C | THR51 |
| C | ARG52 |
| C | PRO266 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 801 |
| Chain | Residue |
| C | ASN248 |
| C | SER249 |
| C | THR274 |
| C | ALA276 |
| C | HOH814 |
| C | HOH834 |
| E | ARG250 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 805 |
| Chain | Residue |
| A | HIS67 |
| B | HIS67 |
| C | GLY66 |
| C | HIS67 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 800 |
| Chain | Residue |
| D | SER50 |
| D | THR51 |
| D | ARG52 |
| D | PRO266 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 801 |
| Chain | Residue |
| D | ASN248 |
| D | SER249 |
| D | THR274 |
| D | ALA276 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 800 |
| Chain | Residue |
| E | SER50 |
| E | THR51 |
| E | ARG52 |
| E | PRO266 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 801 |
| Chain | Residue |
| E | ASN248 |
| E | SER249 |
| E | THR274 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 F 800 |
| Chain | Residue |
| F | SER50 |
| F | THR51 |
| F | ARG52 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 F 801 |
| Chain | Residue |
| F | ASN248 |
| F | SER249 |
| F | THR274 |
| F | ALA276 |
| F | HOH813 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 F 804 |
| Chain | Residue |
| D | ARG54 |
| E | ARG54 |
| F | ARG54 |
Functional Information from PROSITE/UniProt
| site_id | PS00097 |
| Number of Residues | 8 |
| Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FdKnSTRT |
| Chain | Residue | Details |
| A | PHE46-THR53 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 72 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18062991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I6U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| A | CYS264 | |
| A | ASP224 | |
| A | ARG292 | |
| A | GLN131 | |
| A | ARG101 | |
| A | HIS128 |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| D | ARG52 | |
| D | THR53 | |
| D | ARG101 | |
| D | HIS128 |
| site_id | CSA11 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| E | ARG52 | |
| E | THR53 | |
| E | ARG101 | |
| E | HIS128 |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| F | ARG52 | |
| F | THR53 | |
| F | ARG101 | |
| F | HIS128 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| B | CYS264 | |
| B | ASP224 | |
| B | ARG292 | |
| B | GLN131 | |
| B | ARG101 | |
| B | HIS128 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| C | CYS264 | |
| C | ASP224 | |
| C | ARG292 | |
| C | GLN131 | |
| C | ARG101 | |
| C | HIS128 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| D | CYS264 | |
| D | ASP224 | |
| D | ARG292 | |
| D | GLN131 | |
| D | ARG101 | |
| D | HIS128 |
| site_id | CSA5 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| E | CYS264 | |
| E | ASP224 | |
| E | ARG292 | |
| E | GLN131 | |
| E | ARG101 | |
| E | HIS128 |
| site_id | CSA6 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| F | CYS264 | |
| F | ASP224 | |
| F | ARG292 | |
| F | GLN131 | |
| F | ARG101 | |
| F | HIS128 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| A | ARG52 | |
| A | THR53 | |
| A | ARG101 | |
| A | HIS128 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| B | ARG52 | |
| B | THR53 | |
| B | ARG101 | |
| B | HIS128 |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1akm |
| Chain | Residue | Details |
| C | ARG52 | |
| C | THR53 | |
| C | ARG101 | |
| C | HIS128 |
