Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2P1N

Mechanism of Auxin Perception by the TIR1 Ubiqutin Ligase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000151	cellular_component	ubiquitin ligase complex
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0007059	biological_process	chromosome segregation
A	0007140	biological_process	male meiotic nuclear division
A	0009524	cellular_component	phragmoplast
A	0009733	biological_process	response to auxin
A	0009734	biological_process	auxin-activated signaling pathway
A	0009753	biological_process	response to jasmonic acid
A	0009867	biological_process	jasmonic acid mediated signaling pathway
A	0009873	biological_process	ethylene-activated signaling pathway
A	0016567	biological_process	protein ubiquitination
A	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A	0045910	biological_process	negative regulation of DNA recombination
A	0097602	molecular_function	cullin family protein binding
B	0000151	cellular_component	ubiquitin ligase complex
B	0000822	molecular_function	inositol hexakisphosphate binding
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0006952	biological_process	defense response
B	0009733	biological_process	response to auxin
B	0009734	biological_process	auxin-activated signaling pathway
B	0009873	biological_process	ethylene-activated signaling pathway
B	0010011	molecular_function	auxin binding
B	0010152	biological_process	pollen maturation
B	0010311	biological_process	lateral root formation
B	0016036	biological_process	cellular response to phosphate starvation
B	0016567	biological_process	protein ubiquitination
B	0019005	cellular_component	SCF ubiquitin ligase complex
B	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B	0038198	molecular_function	auxin receptor activity
B	0048443	biological_process	stamen development
D	0000151	cellular_component	ubiquitin ligase complex
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005819	cellular_component	spindle
D	0005829	cellular_component	cytosol
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0007059	biological_process	chromosome segregation
D	0007140	biological_process	male meiotic nuclear division
D	0009524	cellular_component	phragmoplast
D	0009733	biological_process	response to auxin
D	0009734	biological_process	auxin-activated signaling pathway
D	0009753	biological_process	response to jasmonic acid
D	0009867	biological_process	jasmonic acid mediated signaling pathway
D	0009873	biological_process	ethylene-activated signaling pathway
D	0016567	biological_process	protein ubiquitination
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0045910	biological_process	negative regulation of DNA recombination
D	0097602	molecular_function	cullin family protein binding
E	0000151	cellular_component	ubiquitin ligase complex
E	0000822	molecular_function	inositol hexakisphosphate binding
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006952	biological_process	defense response
E	0009733	biological_process	response to auxin
E	0009734	biological_process	auxin-activated signaling pathway
E	0009873	biological_process	ethylene-activated signaling pathway
E	0010011	molecular_function	auxin binding
E	0010152	biological_process	pollen maturation
E	0010311	biological_process	lateral root formation
E	0016036	biological_process	cellular response to phosphate starvation
E	0016567	biological_process	protein ubiquitination
E	0019005	cellular_component	SCF ubiquitin ligase complex
E	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E	0038198	molecular_function	auxin receptor activity
E	0048443	biological_process	stamen development

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE IHP B 601

Chain	Residue
B	LYS74
B	ARG484
B	LYS485
B	ARG509
B	HOH634
B	HOH638
B	HIS78
B	LYS113
B	ARG114
B	ARG344
B	ARG401
B	ARG403
B	ARG436
B	MET460

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE IHP E 601

Chain	Residue
E	PHE49
E	LYS74
E	HIS78
E	LYS113
E	ARG114
E	ARG344
E	ARG401
E	ARG403
E	ARG435
E	ARG436
E	ARG484
E	LYS485
E	ARG509
E	HOH791
E	HOH811
E	HOH818

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CFA B 602

Chain	Residue
B	PHE79
B	LEU378
B	ARG403
B	LEU404
B	CYS405
B	SER438
B	LEU439
B	VAL463
B	HOH603
B	HOH659
C	PRO7

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CFA E 602

Chain	Residue
E	PHE79
E	LEU378
E	ARG403
E	LEU404
E	CYS405
E	SER438
E	LEU439
E	VAL463
E	HOH617
E	HOH633
F	PRO7

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Region: {"description":"Interaction with the F-box domain of F-box proteins","evidences":[{"source":"PubMed","id":"17410169","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	22
Details	Region: {"description":"Interaction with auxin-responsive proteins"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17410169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18391211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17410169","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2P1Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Site: {"description":"Interaction with auxin-responsive proteins"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)