2P1B
Crystal structure of human nucleophosmin-core
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | SITE: Interaction between pentamers => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP55 | |
| E | LYS80 | |
| F | ASP55 | |
| F | LYS80 | |
| G | ASP55 | |
| G | LYS80 | |
| H | ASP55 | |
| H | LYS80 | |
| I | ASP55 | |
| I | LYS80 | |
| J | ASP55 | |
| A | LYS80 | |
| J | LYS80 | |
| B | ASP55 | |
| B | LYS80 | |
| C | ASP55 | |
| C | LYS80 | |
| D | ASP55 | |
| D | LYS80 | |
| E | ASP55 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER10 | |
| J | SER10 | |
| B | SER10 | |
| C | SER10 | |
| D | SER10 | |
| E | SER10 | |
| F | SER10 | |
| G | SER10 | |
| H | SER10 | |
| I | SER10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS32 | |
| J | LYS32 | |
| B | LYS32 | |
| C | LYS32 | |
| D | LYS32 | |
| E | LYS32 | |
| F | LYS32 | |
| G | LYS32 | |
| H | LYS32 | |
| I | LYS32 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER43 | |
| J | SER43 | |
| B | SER43 | |
| C | SER43 | |
| D | SER43 | |
| E | SER43 | |
| F | SER43 | |
| G | SER43 | |
| H | SER43 | |
| I | SER43 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q61937 |
| Chain | Residue | Details |
| A | TYR67 | |
| J | TYR67 | |
| B | TYR67 | |
| C | TYR67 | |
| D | TYR67 | |
| E | TYR67 | |
| F | TYR67 | |
| G | TYR67 | |
| H | TYR67 | |
| I | TYR67 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER70 | |
| J | SER70 | |
| B | SER70 | |
| C | SER70 | |
| D | SER70 | |
| E | SER70 | |
| F | SER70 | |
| G | SER70 | |
| H | SER70 | |
| I | SER70 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | THR75 | |
| J | THR75 | |
| B | THR75 | |
| C | THR75 | |
| D | THR75 | |
| E | THR75 | |
| F | THR75 | |
| G | THR75 | |
| H | THR75 | |
| I | THR75 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR95 | |
| J | THR95 | |
| B | THR95 | |
| C | THR95 | |
| D | THR95 | |
| E | THR95 | |
| F | THR95 | |
| G | THR95 | |
| H | THR95 | |
| I | THR95 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447 |
| Chain | Residue | Details |
| A | LYS27 | |
| J | LYS27 | |
| B | LYS27 | |
| C | LYS27 | |
| D | LYS27 | |
| E | LYS27 | |
| F | LYS27 | |
| G | LYS27 | |
| H | LYS27 | |
| I | LYS27 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| E | LYS32 | |
| F | LYS32 | |
| G | LYS32 | |
| H | LYS32 | |
| I | LYS32 | |
| A | LYS32 | |
| J | LYS32 | |
| B | LYS32 | |
| C | LYS32 | |
| D | LYS32 |
