2P03
The structure of receptor-associated protein(RAP)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001540 | molecular_function | amyloid-beta binding |
| A | 0002091 | biological_process | negative regulation of receptor internalization |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005768 | cellular_component | endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005793 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005796 | cellular_component | Golgi lumen |
| A | 0005801 | cellular_component | cis-Golgi network |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0008201 | molecular_function | heparin binding |
| A | 0009986 | cellular_component | cell surface |
| A | 0010916 | biological_process | negative regulation of very-low-density lipoprotein particle clearance |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0031904 | cellular_component | endosome lumen |
| A | 0031982 | cellular_component | vesicle |
| A | 0035473 | molecular_function | lipase binding |
| A | 0048018 | molecular_function | receptor ligand activity |
| A | 0048019 | molecular_function | receptor antagonist activity |
| A | 0048237 | cellular_component | rough endoplasmic reticulum lumen |
| A | 0048259 | biological_process | regulation of receptor-mediated endocytosis |
| A | 0050750 | molecular_function | low-density lipoprotein particle receptor binding |
| A | 0070326 | molecular_function | very-low-density lipoprotein particle receptor binding |
| A | 0150093 | biological_process | amyloid-beta clearance by transcytosis |
| A | 1900116 | biological_process | extracellular negative regulation of signal transduction |
| A | 1900222 | biological_process | negative regulation of amyloid-beta clearance |
| A | 1900223 | biological_process | positive regulation of amyloid-beta clearance |
Functional Information from PROSITE/UniProt
| site_id | PS00014 |
| Number of Residues | 4 |
| Details | ER_TARGET Endoplasmic reticulum targeting sequence. HNEL |
| Chain | Residue | Details |
| A | HIS320-LEU323 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 116 |
| Details | Region: {"description":"LDL receptor binding","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 91 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Motif: {"description":"Prevents secretion from ER","evidences":[{"source":"PubMed","id":"7774585","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 17 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q99068","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P55302","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
