2OZX
Solution structure of human phosphohistidine phosphatase 1 in phosphate free form
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
A | 0004857 | molecular_function | enzyme inhibitor activity |
A | 0005515 | molecular_function | protein binding |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0016604 | cellular_component | nuclear body |
A | 0016787 | molecular_function | hydrolase activity |
A | 0019855 | molecular_function | calcium channel inhibitor activity |
A | 0030036 | biological_process | actin cytoskeleton organization |
A | 0035774 | biological_process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
A | 0044325 | molecular_function | transmembrane transporter binding |
A | 0050860 | biological_process | negative regulation of T cell receptor signaling pathway |
A | 0051015 | molecular_function | actin filament binding |
A | 0061851 | cellular_component | leading edge of lamellipodium |
A | 0070062 | cellular_component | extracellular exosome |
A | 0097581 | biological_process | lamellipodium organization |
A | 0101006 | molecular_function | protein histidine phosphatase activity |
A | 2000147 | biological_process | positive regulation of cell motility |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"18991813","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"18991813","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 6 |
Details | M-CSA 952 |
Chain | Residue | Details |
A | LYS21 | electrostatic stabiliser, modifies pKa |
A | HIS53 | proton acceptor, proton donor |
A | ALA54 | electrostatic stabiliser |
A | ARG78 | electrostatic stabiliser |
A | SER94 | electrostatic stabiliser |
A | ALA96 | electrostatic stabiliser |