2OZW
Solution structure of human phosphohistidine phosphatase 1 with phosphate ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004857 | molecular_function | enzyme inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019855 | molecular_function | calcium channel inhibitor activity |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0035774 | biological_process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0050860 | biological_process | negative regulation of T cell receptor signaling pathway |
| A | 0051015 | molecular_function | actin filament binding |
| A | 0061851 | cellular_component | leading edge of lamellipodium |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0097581 | biological_process | lamellipodium organization |
| A | 0101006 | molecular_function | protein histidine phosphatase activity |
| A | 2000147 | biological_process | positive regulation of cell motility |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 126 |
| Chain | Residue |
| A | LYS21 |
| A | TYR52 |
| A | HIS53 |
| A | ALA54 |
| A | TYR93 |
| A | SER94 |
| A | MET95 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"18991813","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18991813","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 952 |
| Chain | Residue | Details |
| A | LYS21 | electrostatic stabiliser, modifies pKa |
| A | HIS53 | proton acceptor, proton donor |
| A | ALA54 | electrostatic stabiliser |
| A | ARG78 | electrostatic stabiliser |
| A | SER94 | electrostatic stabiliser |
| A | ALA96 | electrostatic stabiliser |
