2OZU
Crystal structure of human MYST histone acetyltransferase 3 in complex with acetylcoenzyme A
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 800 |
| Chain | Residue |
| A | CYS540 |
| A | CYS543 |
| A | HIS556 |
| A | CYS560 |
| site_id | AC2 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE ACO A 850 |
| Chain | Residue |
| A | HOH36 |
| A | HOH70 |
| A | HOH86 |
| A | LYS516 |
| A | TYR517 |
| A | GLU518 |
| A | TRP522 |
| A | PHE600 |
| A | LEU601 |
| A | SER645 |
| A | ILE647 |
| A | MET648 |
| A | ILE649 |
| A | GLN654 |
| A | ARG655 |
| A | LYS656 |
| A | GLY657 |
| A | GLY659 |
| A | ARG660 |
| A | LEU683 |
| A | SER684 |
| A | LEU686 |
| A | LEU689 |
| A | SER690 |
| A | ALA693 |
| A | ACM903 |
| A | HOH2 |
| A | HOH3 |
| A | HOH20 |
| A | HOH21 |
| A | HOH30 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACM A 901 |
| Chain | Residue |
| A | LYS573 |
| A | HIS705 |
| A | CYS773 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACM A 902 |
| Chain | Residue |
| A | GLU635 |
| A | CYS638 |
| A | GLN639 |
| A | GLN640 |
| A | TYR642 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACM A 903 |
| Chain | Residue |
| A | ALY604 |
| A | SER645 |
| A | CYS646 |
| A | ACO850 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACM A 904 |
| Chain | Residue |
| A | ILE588 |
| A | GLN591 |
| A | CYS723 |
| A | PRO724 |
| A | GLN725 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | Zinc finger: {"description":"C2HC MYST-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01063","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q9H7Z6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"The crystal structure of human MYST histone acetyltransferase 3 in complex with acetylcoenzyme A.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"The crystal structure of human MYST histone acetyltransferase 3 in complex with acetylcoenzyme A.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mj9 |
| Chain | Residue | Details |
| A | CYS646 | |
| A | GLU680 |
