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2OZR

MMP13 Catalytic Domain Complexed with 4-{[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl}benzoic acid

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0031012cellular_componentextracellular matrix
B0004222molecular_functionmetalloendopeptidase activity
B0006508biological_processproteolysis
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0031012cellular_componentextracellular matrix
C0004222molecular_functionmetalloendopeptidase activity
C0006508biological_processproteolysis
C0008237molecular_functionmetallopeptidase activity
C0008270molecular_functionzinc ion binding
C0031012cellular_componentextracellular matrix
D0004222molecular_functionmetalloendopeptidase activity
D0006508biological_processproteolysis
D0008237molecular_functionmetallopeptidase activity
D0008270molecular_functionzinc ion binding
D0031012cellular_componentextracellular matrix
E0004222molecular_functionmetalloendopeptidase activity
E0006508biological_processproteolysis
E0008237molecular_functionmetallopeptidase activity
E0008270molecular_functionzinc ion binding
E0031012cellular_componentextracellular matrix
F0004222molecular_functionmetalloendopeptidase activity
F0006508biological_processproteolysis
F0008237molecular_functionmetallopeptidase activity
F0008270molecular_functionzinc ion binding
F0031012cellular_componentextracellular matrix
G0004222molecular_functionmetalloendopeptidase activity
G0006508biological_processproteolysis
G0008237molecular_functionmetallopeptidase activity
G0008270molecular_functionzinc ion binding
G0031012cellular_componentextracellular matrix
H0004222molecular_functionmetalloendopeptidase activity
H0006508biological_processproteolysis
H0008237molecular_functionmetallopeptidase activity
H0008270molecular_functionzinc ion binding
H0031012cellular_componentextracellular matrix
Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL
ChainResidueDetails
AVAL198-LEU207

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues560
DetailsRegion: {"description":"Interaction with TIMP2"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues8
DetailsActive site: {"evidences":[{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues96
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10926524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10986126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15734645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15780611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17623656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19422229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20005097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20726512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22689580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23810497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8969305","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues64
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10926524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10986126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15734645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15780611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17623656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19422229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20005097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20726512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22689580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23810497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"8576151","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
AMET219
AGLU202

site_idCSA10
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
BGLU202

site_idCSA11
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
CGLU202

site_idCSA12
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
DGLU202

site_idCSA13
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
EGLU202

site_idCSA14
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
FGLU202

site_idCSA15
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
GGLU202

site_idCSA16
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
HGLU202

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
BMET219
BGLU202

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
CMET219
CGLU202

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
DMET219
DGLU202

site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
EMET219
EGLU202

site_idCSA6
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
FMET219
FGLU202

site_idCSA7
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
GMET219
GGLU202

site_idCSA8
Number of Residues2
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
HMET219
HGLU202

site_idCSA9
Number of Residues1
DetailsAnnotated By Reference To The Literature 1hfs
ChainResidueDetails
AGLU202

243083

PDB entries from 2025-10-15

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