2OZ6
Crystal Structure of Virulence Factor Regulator from Pseudomonas aeruginosa in complex with cAMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0001216 | molecular_function | DNA-binding transcription activator activity |
| A | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0030552 | molecular_function | cAMP binding |
| A | 0032993 | cellular_component | protein-DNA complex |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CMP A 302 |
| Chain | Residue |
| A | ARG59 |
| A | ARG185 |
| A | GLU60 |
| A | ALA140 |
| A | GLN175 |
| A | GLY178 |
| A | ARG179 |
| A | GLY182 |
| A | CYS183 |
| A | SER184 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CMP A 301 |
| Chain | Residue |
| A | CYS38 |
| A | ILE63 |
| A | PHE72 |
| A | GLY73 |
| A | GLU74 |
| A | LEU75 |
| A | GLY76 |
| A | ARG87 |
| A | SER88 |
| A | ALA89 |
| A | ARG128 |
| A | LEU129 |
| A | THR132 |
| A | THR133 |
| A | HOH311 |
Functional Information from PROSITE/UniProt
| site_id | PS00042 |
| Number of Residues | 24 |
| Details | HTH_CRP_1 Crp-type HTH domain signature. ITRqeIGrIVGcSreMv.GRvLksL |
| Chain | Residue | Details |
| A | ILE172-LEU195 |
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIyAGDrCEtLFFIikG |
| Chain | Residue | Details |
| A | ILE31-GLY47 |
| site_id | PS00889 |
| Number of Residues | 22 |
| Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElGLfekegseqe..RSAwVrA |
| Chain | Residue | Details |
| A | PHE72-ALA93 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00387 |
| Chain | Residue | Details |
| A | ARG174-LYS193 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21665969, ECO:0007744|PDB:2OZ6 |
| Chain | Residue | Details |
| A | ARG59 | |
| A | GLY73 | |
| A | ARG87 | |
| A | THR132 | |
| A | ARG179 | |
| A | ARG185 |
