2OYU

Indomethacin-(S)-alpha-ethyl-ethanolamide bound to Cyclooxygenase-1

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0004601	molecular_function	peroxidase activity
P	0006979	biological_process	response to oxidative stress
P	0020037	molecular_function	heme binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	TRANSMEM: Helical

Chain	Residue	Details
P	ILE74-LEU82
P	PRO86-LEU92
P	ARG97-ALA105
P	ILE108-ASN122

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
P	HIS207

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site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: For cyclooxygenase activity => ECO:0000269|PubMed:2122967

Chain	Residue	Details
P	TYR385

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: axial binding residue

Chain	Residue	Details
P	HIS388

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Not glycosylated => ECO:0000269|PubMed:8349699

Chain	Residue	Details
P	ASN104

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site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Aspirin-acetylated serine

Chain	Residue	Details
P	SER530

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site_id	SWS_FT_FI7
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8349699

Chain	Residue	Details
P	ASN68
P	ASN144
P	ASN410

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1mhl

Chain	Residue	Details
P	VAL291

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site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1mhl

Chain	Residue	Details
P	HIS207
P	TYR385
P	GLN203

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