Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003911 | molecular_function | DNA ligase (NAD+) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006260 | biological_process | DNA replication |
| A | 0006281 | biological_process | DNA repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 672 |
| Chain | Residue |
| A | CYS408 |
| A | CYS411 |
| A | CYS426 |
| A | CYS432 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 673 |
| Chain | Residue |
| A | ARG446 |
| A | ARG447 |
| A | HOH922 |
| C | HOH42 |
| D | DC40 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 674 |
| Chain | Residue |
| A | ARG74 |
| A | ARG510 |
| A | HOH718 |
| A | HOH759 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 675 |
| Chain | Residue |
| A | ASN95 |
| A | GLN99 |
| A | SER262 |
| A | ALA263 |
| A | HOH799 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 676 |
| Chain | Residue |
| A | HIS559 |
| A | ASN562 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE AMP D 53 |
| Chain | Residue |
| A | SER81 |
| A | LEU82 |
| A | GLU113 |
| A | LYS115 |
| A | ALA120 |
| A | ARG136 |
| A | GLU173 |
| A | TYR225 |
| A | VAL288 |
| A | LYS290 |
| A | HOH752 |
| C | HOH137 |
| D | DC40 |
Functional Information from PROSITE/UniProt
| site_id | PS01055 |
| Number of Residues | 30 |
| Details | DNA_LIGASE_N1 NAD-dependent DNA ligase signature 1. KLDGLAvsilYenGvLvsaaTRGDGttGED |
| Chain | Residue | Details |
| A | LYS115-ASP144 | |
| site_id | PS01056 |
| Number of Residues | 16 |
| Details | DNA_LIGASE_N2 NAD-dependent DNA ligase signature 2. VGRTGaITpVarLePV |
| Chain | Residue | Details |
| A | VAL331-VAL346 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | Region: {"description":"Interaction with target DNA","evidences":[{"source":"PubMed","id":"17466627","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"N6-AMP-lysine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01588","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11781321","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01588","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01588","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17466627","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01588","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17466627","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with target DNA","evidences":[{"source":"PubMed","id":"17466627","evidenceCode":"ECO:0000305"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1b04 |
| Chain | Residue | Details |
| A | LYS115 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1b04 |
| Chain | Residue | Details |
| A | ARG200 | |
| A | ASP117 | |
| A | LYS314 | |
| A | LYS115 | |
