2OV5

Crystal structure of the KPC-2 carbapenemase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030655	biological_process	beta-lactam antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0030655	biological_process	beta-lactam antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0030655	biological_process	beta-lactam antibiotic catabolic process
C	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BCN A 501

Chain	Residue
A	SER70
A	TRP105
A	SER130
A	LYS234
A	THR235
A	THR237
A	HOH591

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE BCN B 502

Chain	Residue
B	TRP105
B	SER130
B	ASN132
B	THR216
B	LYS234
B	THR235
B	GLY236
B	THR237
B	SER70
B	LYS73

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE BCN C 503

Chain	Residue
C	SER70
C	LYS73
C	TRP105
C	SER130
C	ASN132
C	LYS234
C	THR235
C	GLY236
C	THR237
C	HOH548
C	HOH552

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Nucleophile; acyl-ester intermediate => ECO:0000269|PubMed:33257320, ECO:0007744|PDB:6Z23, ECO:0007744|PDB:6Z24

Chain	Residue	Details
A	SER70
B	SER70
C	SER70

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	GLU168
B	GLU168
C	GLU168

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0000269|PubMed:33257320, ECO:0007744|PDB:5UJ3, ECO:0007744|PDB:6Z23, ECO:0007744|PDB:6Z24

Chain	Residue	Details
A	SER70
A	THR237
B	SER70
B	THR237
C	SER70
C	THR237

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0007744|PDB:5UJ3

Chain	Residue	Details
A	LYS73
B	LYS73
C	LYS73

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:33257320, ECO:0000312|PDB:6Z24

Chain	Residue	Details
A	TRP105
B	TRP105
C	TRP105

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0000269|PubMed:33257320, ECO:0007744|PDB:5UJ3, ECO:0007744|PDB:6Z23

Chain	Residue	Details
A	SER130
B	SER130
C	SER130

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:33257320, ECO:0007744|PDB:6Z23, ECO:0007744|PDB:6Z24

Chain	Residue	Details
A	ASN132
B	ASN132
C	ASN132

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:28388065, ECO:0007744|PDB:5UJ3, ECO:0007744|PDB:6Z24

Chain	Residue	Details
A	THR235
B	THR235
C	THR235

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1btl

Chain	Residue	Details
A	GLU166
A	LYS73
A	SER130
A	SER70

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1btl

Chain	Residue	Details
B	GLU166
B	LYS73
B	SER130
B	SER70

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1btl

Chain	Residue	Details
C	GLU166
C	LYS73
C	SER130
C	SER70

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