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2OV4

Crystal structure of B. stearothermophilus tryptophanyl tRNA synthetase in complex with adenosine tetraphosphate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004812molecular_functionaminoacyl-tRNA ligase activity
A0004830molecular_functiontryptophan-tRNA ligase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006412biological_processtranslation
A0006418biological_processtRNA aminoacylation for protein translation
A0006436biological_processtryptophanyl-tRNA aminoacylation
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CS A 900
ChainResidue
AMET1
AGLN30
ATYR33
AGLN74

site_idAC2
Number of Residues23
DetailsBINDING SITE FOR RESIDUE AQP A 400
ChainResidue
AASN18
AGLY21
AALA22
ALYS111
AVAL143
AGLY144
AASP146
AGLN147
AGLY180
AALA181
AILE183
ALYS192
AMET193
ASER194
ALYS195
ASER196
AHOH513
AHOH541
AGLY7
AILE8
AGLN9
ASER11
AGLY17

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ANL A 950
ChainResidue
APHE5
AGLY7
AVAL40
AHIS43
AMET129
AASP132
AVAL143

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 930
ChainResidue
ALYS218
ATHR222
ATYR265
AGLY266
ALYS269
AHOH553

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 940
ChainResidue
AARG60
ATYR287
AHIS288
AMET291

Functional Information from PROSITE/UniProt
site_idPS00178
Number of Residues10
DetailsAA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..SGvITIGNY
ChainResidueDetails
APRO10-TYR19

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00140, ECO:0000269|PubMed:26555258, ECO:0007744|PDB:5DK4
ChainResidueDetails
AGLN9
AGLY17
AASP132
AGLY144
AILE183
ALYS192

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1d2r
ChainResidueDetails
ALYS192
ALYS195

site_idMCSA1
Number of Residues3
DetailsM-CSA 481
ChainResidueDetails
ALYS111electrostatic stabiliser
ALYS192electrostatic stabiliser
ALYS195electrostatic stabiliser

227111

PDB entries from 2024-11-06

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