2OUL

The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
B	0005515	molecular_function	protein binding
B	0009986	cellular_component	cell surface
B	0020016	cellular_component	ciliary pocket
B	0031410	cellular_component	cytoplasmic vesicle

Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QKnCGSCWAfSS

Chain	Residue	Details
A	GLN19-SER30

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site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVMLVGFG

Chain	Residue	Details
A	LEU155-GLY165

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10088

Chain	Residue	Details
A	CYS25

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089

Chain	Residue	Details
A	HIS157

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site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090

Chain	Residue	Details
A	ASN187

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	ASN187
A	CYS25
A	HIS157

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site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	GLN19
A	CYS25
A	HIS157

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site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1pad

Chain	Residue	Details
A	ASN187
A	GLN19
A	HIS157

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