2OUL
The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of a New Inhibitor Family
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0009986 | cellular_component | cell surface |
| B | 0020016 | cellular_component | ciliary pocket |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QKnCGSCWAfSS |
| Chain | Residue | Details |
| A | GLN19-SER30 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVMLVGFG |
| Chain | Residue | Details |
| A | LEU155-GLY165 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Nose motif; required for the correct folding of the mature form","evidences":[{"source":"PubMed","id":"11827964","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Motif: {"description":"Arm motif; binds to host hemoglobin and required for the inhibitory interaction between the propeptide and the catalytic domain","evidences":[{"source":"PubMed","id":"15964982","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | Motif: {"description":"BC loop","evidences":[{"source":"PubMed","id":"17502099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17561110","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18515357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19143838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 9 |
| Details | Motif: {"description":"DE loop","evidences":[{"source":"PubMed","id":"17502099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17561110","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18515357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19143838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 9 |
| Details | Motif: {"description":"FG loop","evidences":[{"source":"PubMed","id":"17502099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17561110","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18515357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19143838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | ASN187 | |
| A | CYS25 | |
| A | HIS157 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | GLN19 | |
| A | CYS25 | |
| A | HIS157 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | ASN187 | |
| A | GLN19 | |
| A | HIS157 |
