2OU2

Acetyltransferase domain of Human HIV-1 Tat interacting protein, 60kDa, isoform 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 490

Chain	Residue
A	CYS211
A	CYS214
A	HIS227
A	CYS231

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site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ACO A 500

Chain	Residue
A	ARG189
A	TRP193
A	PHE271
A	LEU272
A	ALA316
A	CYS317
A	ILE318
A	LEU319
A	THR320
A	GLN325
A	ARG326
A	ARG327
A	GLY328
A	GLY330
A	LYS331
A	GLU351
A	SER355
A	LEU357
A	SER361
A	SER364
A	GLN368
A	HOH1
A	HOH7
A	HOH25
A	ARG187
A	HIS188

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	ZN_FING: C2HC MYST-type => ECO:0000255|PROSITE-ProRule:PRU01063, ECO:0000305|Ref.69

Chain	Residue	Details
A	LEU208-LEU233

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:Q9H7Z6

Chain	Residue	Details
A	GLU351

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|Ref.69

Chain	Residue	Details
A	ILE318
A	GLN325
A	SER355

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9H7Z6

Chain	Residue	Details
A	SER364

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:24835996, ECO:0000269|Ref.69

Chain	Residue	Details
A	ALY275

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000269|PubMed:32832608

Chain	Residue	Details
A	LYS378

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000269|PubMed:17704809

Chain	Residue	Details
A	LYS399

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