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2OPR

Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003964molecular_functionRNA-directed DNA polymerase activity
A0004523molecular_functionRNA-DNA hybrid ribonuclease activity
A0006278biological_processRNA-templated DNA biosynthetic process
B0003964molecular_functionRNA-directed DNA polymerase activity
B0006278biological_processRNA-templated DNA biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE HBQ A 999
ChainResidue
ALEU100
ATRP229
ALEU234
AHIS235
ATYR318
AGLU101
ALYS103
AVAL106
AVAL179
ATYR181
ATYR188
AGLY190
APHE227

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BASP110
BASP185
BASP186

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Essential for RT p66/p51 heterodimerization => ECO:0000250
ChainResidueDetails
BTRP401
BTRP414

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:12206668
ChainResidueDetails
AGLU478

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Essential for RT p66/p51 heterodimerization => ECO:0000250
ChainResidueDetails
ATRP401
ATRP414

site_idSWS_FT_FI5
Number of Residues1
DetailsSITE: Cleavage; by viral protease; partial => ECO:0000250
ChainResidueDetails
APHE440

Catalytic Information from CSA
site_idMCSA1
Number of Residues
DetailsM-CSA 175
ChainResidueDetails

226707

PDB entries from 2024-10-30

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