2OM9
Ajulemic acid, a synthetic cannabinoid bound to PPAR gamma
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0004879 | molecular_function | nuclear receptor activity |
A | 0005634 | cellular_component | nucleus |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0003677 | molecular_function | DNA binding |
B | 0004879 | molecular_function | nuclear receptor activity |
B | 0005634 | cellular_component | nucleus |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
C | 0003677 | molecular_function | DNA binding |
C | 0004879 | molecular_function | nuclear receptor activity |
C | 0005634 | cellular_component | nucleus |
C | 0006355 | biological_process | regulation of DNA-templated transcription |
D | 0003677 | molecular_function | DNA binding |
D | 0004879 | molecular_function | nuclear receptor activity |
D | 0005634 | cellular_component | nucleus |
D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE AJA A 501 |
Chain | Residue |
A | PHE264 |
A | LYS265 |
A | HIS266 |
A | CYS285 |
A | ARG288 |
A | VAL339 |
A | SER342 |
A | MET348 |
A | LEU353 |
site_id | AC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE AJA B 502 |
Chain | Residue |
A | LYS301 |
A | GLN314 |
A | VAL315 |
A | LEU318 |
A | AJA602 |
B | VAL290 |
B | GLN294 |
B | HIS466 |
B | LEU468 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE AJA B 601 |
Chain | Residue |
B | HOH102 |
B | PHE264 |
B | LYS265 |
B | CYS285 |
B | VAL339 |
B | ILE341 |
B | SER342 |
B | MET348 |
B | LEU353 |
B | PHE360 |
site_id | AC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE AJA A 602 |
Chain | Residue |
A | HOH61 |
A | HOH155 |
A | VAL290 |
A | HIS466 |
A | PRO467 |
A | LEU468 |
B | LYS301 |
B | LEU311 |
B | VAL315 |
B | AJA502 |
site_id | AC5 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE AJA C 701 |
Chain | Residue |
C | PHE264 |
C | LYS265 |
C | HIS266 |
C | GLY284 |
C | CYS285 |
C | ARG288 |
C | SER342 |
C | PHE360 |
C | HOH724 |
site_id | AC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE AJA C 702 |
Chain | Residue |
C | VAL293 |
C | THR297 |
C | LYS301 |
C | VAL315 |
C | LEU318 |
C | HOH717 |
C | HOH733 |
D | VAL290 |
D | HIS466 |
D | LEU468 |
site_id | AC7 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE AJA D 801 |
Chain | Residue |
C | HIS466 |
C | PRO467 |
C | LEU468 |
C | GLU471 |
C | HOH717 |
C | HOH731 |
C | HOH736 |
D | THR297 |
D | LYS301 |
D | VAL315 |
D | LEU318 |
D | ILE472 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE AJA D 802 |
Chain | Residue |
D | PHE264 |
D | HIS266 |
D | CYS285 |
D | ILE341 |
D | SER342 |
D | MET348 |
D | PHE360 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG |
Chain | Residue | Details |
A | GLN286 | |
C | HIS323 | |
C | HIS449 | |
C | TYR473 | |
D | GLN286 | |
D | HIS323 | |
D | HIS449 | |
D | TYR473 | |
A | HIS323 | |
A | HIS449 | |
A | TYR473 | |
B | GLN286 | |
B | HIS323 | |
B | HIS449 | |
B | TYR473 | |
C | GLN286 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 |
Chain | Residue | Details |
A | LYS224 | |
B | LYS224 | |
C | LYS224 | |
D | LYS224 |