2OM9
Ajulemic acid, a synthetic cannabinoid bound to PPAR gamma
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0004879 | molecular_function | nuclear receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004879 | molecular_function | nuclear receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AJA A 501 |
| Chain | Residue |
| A | PHE264 |
| A | LYS265 |
| A | HIS266 |
| A | CYS285 |
| A | ARG288 |
| A | VAL339 |
| A | SER342 |
| A | MET348 |
| A | LEU353 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AJA B 502 |
| Chain | Residue |
| A | LYS301 |
| A | GLN314 |
| A | VAL315 |
| A | LEU318 |
| A | AJA602 |
| B | VAL290 |
| B | GLN294 |
| B | HIS466 |
| B | LEU468 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AJA B 601 |
| Chain | Residue |
| B | HOH102 |
| B | PHE264 |
| B | LYS265 |
| B | CYS285 |
| B | VAL339 |
| B | ILE341 |
| B | SER342 |
| B | MET348 |
| B | LEU353 |
| B | PHE360 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AJA A 602 |
| Chain | Residue |
| A | HOH61 |
| A | HOH155 |
| A | VAL290 |
| A | HIS466 |
| A | PRO467 |
| A | LEU468 |
| B | LYS301 |
| B | LEU311 |
| B | VAL315 |
| B | AJA502 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AJA C 701 |
| Chain | Residue |
| C | PHE264 |
| C | LYS265 |
| C | HIS266 |
| C | GLY284 |
| C | CYS285 |
| C | ARG288 |
| C | SER342 |
| C | PHE360 |
| C | HOH724 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AJA C 702 |
| Chain | Residue |
| C | VAL293 |
| C | THR297 |
| C | LYS301 |
| C | VAL315 |
| C | LEU318 |
| C | HOH717 |
| C | HOH733 |
| D | VAL290 |
| D | HIS466 |
| D | LEU468 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE AJA D 801 |
| Chain | Residue |
| C | HIS466 |
| C | PRO467 |
| C | LEU468 |
| C | GLU471 |
| C | HOH717 |
| C | HOH731 |
| C | HOH736 |
| D | THR297 |
| D | LYS301 |
| D | VAL315 |
| D | LEU318 |
| D | ILE472 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE AJA D 802 |
| Chain | Residue |
| D | PHE264 |
| D | HIS266 |
| D | CYS285 |
| D | ILE341 |
| D | SER342 |
| D | MET348 |
| D | PHE360 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG |
| Chain | Residue | Details |
| A | GLN286 | |
| C | HIS323 | |
| C | HIS449 | |
| C | TYR473 | |
| D | GLN286 | |
| D | HIS323 | |
| D | HIS449 | |
| D | TYR473 | |
| A | HIS323 | |
| A | HIS449 | |
| A | TYR473 | |
| B | GLN286 | |
| B | HIS323 | |
| B | HIS449 | |
| B | TYR473 | |
| C | GLN286 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 |
| Chain | Residue | Details |
| A | LYS224 | |
| B | LYS224 | |
| C | LYS224 | |
| D | LYS224 |
