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2OM1

Structure of human insulin in presence of thiocyanate at pH 6.5

Functional Information from GO Data
ChainGOidnamespacecontents
10005179molecular_functionhormone activity
10005576cellular_componentextracellular region
20005179molecular_functionhormone activity
20005576cellular_componentextracellular region
30005179molecular_functionhormone activity
30005576cellular_componentextracellular region
40005179molecular_functionhormone activity
40005576cellular_componentextracellular region
a0005179molecular_functionhormone activity
a0005576cellular_componentextracellular region
A0005179molecular_functionhormone activity
A0005576cellular_componentextracellular region
b0005179molecular_functionhormone activity
b0005576cellular_componentextracellular region
B0005179molecular_functionhormone activity
B0005576cellular_componentextracellular region
c0005179molecular_functionhormone activity
c0005576cellular_componentextracellular region
C0005179molecular_functionhormone activity
C0005576cellular_componentextracellular region
d0005179molecular_functionhormone activity
d0005576cellular_componentextracellular region
D0005179molecular_functionhormone activity
D0005576cellular_componentextracellular region
e0005179molecular_functionhormone activity
e0005576cellular_componentextracellular region
E0005179molecular_functionhormone activity
E0005576cellular_componentextracellular region
f0005179molecular_functionhormone activity
f0005576cellular_componentextracellular region
F0005179molecular_functionhormone activity
F0005576cellular_componentextracellular region
g0005179molecular_functionhormone activity
g0005576cellular_componentextracellular region
G0005179molecular_functionhormone activity
G0005576cellular_componentextracellular region
h0005179molecular_functionhormone activity
h0005576cellular_componentextracellular region
H0005179molecular_functionhormone activity
H0005576cellular_componentextracellular region
i0005179molecular_functionhormone activity
i0005576cellular_componentextracellular region
I0005179molecular_functionhormone activity
I0005576cellular_componentextracellular region
j0005179molecular_functionhormone activity
j0005576cellular_componentextracellular region
J0005179molecular_functionhormone activity
J0005576cellular_componentextracellular region
k0005179molecular_functionhormone activity
k0005576cellular_componentextracellular region
K0005179molecular_functionhormone activity
K0005576cellular_componentextracellular region
l0005179molecular_functionhormone activity
l0005576cellular_componentextracellular region
L0005179molecular_functionhormone activity
L0005576cellular_componentextracellular region
Q0005179molecular_functionhormone activity
Q0005576cellular_componentextracellular region
R0005179molecular_functionhormone activity
R0005576cellular_componentextracellular region
S0005179molecular_functionhormone activity
S0005576cellular_componentextracellular region
T0005179molecular_functionhormone activity
T0005576cellular_componentextracellular region
U0005179molecular_functionhormone activity
U0005576cellular_componentextracellular region
V0005179molecular_functionhormone activity
V0005576cellular_componentextracellular region
X0005179molecular_functionhormone activity
X0005576cellular_componentextracellular region
Y0005179molecular_functionhormone activity
Y0005576cellular_componentextracellular region
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 801
ChainResidue
BHIS10
BSCN905
FHIS10
JHIS10

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 802
ChainResidue
DHIS10
DSCN906
HHIS10
LHIS10

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN R 803
ChainResidue
RSCN903
THIS10
VHIS10
RHIS10

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN Y 804
ChainResidue
2HIS10
4HIS10
YHIS10
YSCN904

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN h 805
ChainResidue
hHIS10
hSCN902
jHIS10
lHIS10

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN b 806
ChainResidue
bHIS10
bSCN901
dHIS10
fHIS10

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SCN b 901
ChainResidue
bHIS10
bZN806
dHIS10
fHIS10

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SCN h 902
ChainResidue
hHIS10
hZN805
jHIS10
lHIS10

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SCN R 903
ChainResidue
RHIS10
RZN803
TLEU6
THIS10
VLEU6
VHIS10

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SCN Y 904
ChainResidue
2HIS10
4HIS10
YHIS10
YZN804

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SCN B 905
ChainResidue
BHIS10
BZN801
FHIS10
JHIS10

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SCN D 906
ChainResidue
DHIS10
DZN802
HHIS10
LHIS10

site_idBC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE RCO U 1001
ChainResidue
RHIS5
UCYS6
USER9
UILE10
UCYS11
UHOH1003
VLEU11
YLEU17

site_idBC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE RCO G 1002
ChainResidue
BLEU17
DHIS5
GCYS6
GILE10
GCYS11
GHOH1018
HLEU11
HALA14

site_idBC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE RCO Q 1003
ChainResidue
2LEU17
QCYS6
QSER9
QILE10
QCYS11
QHOH1021
RLEU11
RALA14
THIS5

site_idBC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE RCO K 1004
ChainResidue
FLEU17
HHIS5
KCYS6
KILE10
KCYS11
KHOH1005
LLEU11
LALA14

site_idBC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE RCO e 1005
ChainResidue
dHIS5
eCYS6
eILE10
eCYS11
eHOH1010
fLEU11
fALA14
hLEU17

site_idBC9
Number of Residues9
DetailsBINDING SITE FOR RESIDUE RCO 3 1006
ChainResidue
TLEU17
2HIS5
3CYS6
3SER9
3ILE10
3CYS11
3HOH1018
4LEU11
4ALA14

site_idCC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE RCO 1 1007
ChainResidue
1CYS6
1SER9
1ILE10
1CYS11
1HOH1011
2LEU11
2ALA14
RLEU17
YHIS5

site_idCC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE RCO S 1008
ChainResidue
4LEU17
SCYS6
SSER9
SILE10
SCYS11
SHOH1016
SHOH1025
TLEU11
TALA14

site_idCC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE RCO C 1009
ChainResidue
CCYS6
CSER9
CILE10
CCYS11
CHOH1010
DLEU11
DALA14
JLEU17
LHIS5
LHOH33

site_idCC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE RCO g 1010
ChainResidue
fLEU17
gCYS6
gSER9
gILE10
gCYS11
gHOH1016
hLEU11
hALA14
jHIS5

site_idCC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE RCO A 1011
ChainResidue
ACYS6
ASER9
AILE10
ACYS11
AHOH1033
BLEU11
BALA14
FHIS5
HLEU17

site_idCC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE RCO c 1012
ChainResidue
bHIS5
cCYS6
cSER9
cILE10
cCYS11
cHOH1016
dLEU11
dALA14
lLEU17

site_idCC7
Number of Residues9
DetailsBINDING SITE FOR RESIDUE RCO I 1013
ChainResidue
BHIS5
DLEU17
ICYS6
ISER9
IILE10
ICYS11
IHOH1018
JLEU11
JALA14

site_idCC8
Number of Residues9
DetailsBINDING SITE FOR RESIDUE RCO E 1014
ChainResidue
ECYS6
ESER9
EILE10
ECYS11
EHOH1017
FLEU11
FALA14
JHIS5
LLEU17

site_idCC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE RCO X 1015
ChainResidue
4HIS5
VLEU17
XCYS6
XSER9
XILE10
XCYS11
XHOH1016
XHOH1034
YLEU11
YALA14

site_idDC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE RCO a 1016
ChainResidue
aCYS6
aSER9
aILE10
aCYS11
aLEU16
aHOH1018
bLEU11
bALA14
fHIS5
jLEU17

site_idDC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE RCO k 1017
ChainResidue
dLEU17
hHIS5
kCYS6
kSER9
kILE10
kCYS11
kHOH1019
lLEU11
lALA14

site_idDC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE RCO i 1018
ChainResidue
bLEU17
iCYS6
iSER9
iILE10
iCYS11
iHOH1021
jLEU11
jALA14
lHIS5

site_idDC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL T 1101
ChainResidue
QTHR8
QSER9
TPHE1
THOH1104
THOH1113
THOH1117
THOH1125
THOH1132
cASN18

Functional Information from PROSITE/UniProt
site_idPS00262
Number of Residues15
DetailsINSULIN Insulin family signature. CCTSiCSlyqLenyC
ChainResidueDetails
ACYS6-CYS20

225158

PDB entries from 2024-09-18

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