Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2OM1

Structure of human insulin in presence of thiocyanate at pH 6.5

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005179	molecular_function	hormone activity
1	0005576	cellular_component	extracellular region
2	0005179	molecular_function	hormone activity
2	0005576	cellular_component	extracellular region
3	0005179	molecular_function	hormone activity
3	0005576	cellular_component	extracellular region
4	0005179	molecular_function	hormone activity
4	0005576	cellular_component	extracellular region
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
E	0005179	molecular_function	hormone activity
E	0005576	cellular_component	extracellular region
F	0005179	molecular_function	hormone activity
F	0005576	cellular_component	extracellular region
G	0005179	molecular_function	hormone activity
G	0005576	cellular_component	extracellular region
H	0005179	molecular_function	hormone activity
H	0005576	cellular_component	extracellular region
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
J	0005179	molecular_function	hormone activity
J	0005576	cellular_component	extracellular region
K	0005179	molecular_function	hormone activity
K	0005576	cellular_component	extracellular region
L	0005179	molecular_function	hormone activity
L	0005576	cellular_component	extracellular region
Q	0005179	molecular_function	hormone activity
Q	0005576	cellular_component	extracellular region
R	0005179	molecular_function	hormone activity
R	0005576	cellular_component	extracellular region
S	0005179	molecular_function	hormone activity
S	0005576	cellular_component	extracellular region
T	0005179	molecular_function	hormone activity
T	0005576	cellular_component	extracellular region
U	0005179	molecular_function	hormone activity
U	0005576	cellular_component	extracellular region
V	0005179	molecular_function	hormone activity
V	0005576	cellular_component	extracellular region
X	0005179	molecular_function	hormone activity
X	0005576	cellular_component	extracellular region
Y	0005179	molecular_function	hormone activity
Y	0005576	cellular_component	extracellular region
a	0005179	molecular_function	hormone activity
a	0005576	cellular_component	extracellular region
b	0005179	molecular_function	hormone activity
b	0005576	cellular_component	extracellular region
c	0005179	molecular_function	hormone activity
c	0005576	cellular_component	extracellular region
d	0005179	molecular_function	hormone activity
d	0005576	cellular_component	extracellular region
e	0005179	molecular_function	hormone activity
e	0005576	cellular_component	extracellular region
f	0005179	molecular_function	hormone activity
f	0005576	cellular_component	extracellular region
g	0005179	molecular_function	hormone activity
g	0005576	cellular_component	extracellular region
h	0005179	molecular_function	hormone activity
h	0005576	cellular_component	extracellular region
i	0005179	molecular_function	hormone activity
i	0005576	cellular_component	extracellular region
j	0005179	molecular_function	hormone activity
j	0005576	cellular_component	extracellular region
k	0005179	molecular_function	hormone activity
k	0005576	cellular_component	extracellular region
l	0005179	molecular_function	hormone activity
l	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 801

Chain	Residue
B	HIS10
B	SCN905
F	HIS10
J	HIS10

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 802

Chain	Residue
D	HIS10
D	SCN906
H	HIS10
L	HIS10

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN R 803

Chain	Residue
R	SCN903
T	HIS10
V	HIS10
R	HIS10

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Y 804

Chain	Residue
2	HIS10
4	HIS10
Y	HIS10
Y	SCN904

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN h 805

Chain	Residue
h	HIS10
h	SCN902
j	HIS10
l	HIS10

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN b 806

Chain	Residue
b	HIS10
b	SCN901
d	HIS10
f	HIS10

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SCN b 901

Chain	Residue
b	HIS10
b	ZN806
d	HIS10
f	HIS10

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SCN h 902

Chain	Residue
h	HIS10
h	ZN805
j	HIS10
l	HIS10

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SCN R 903

Chain	Residue
R	HIS10
R	ZN803
T	LEU6
T	HIS10
V	LEU6
V	HIS10

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SCN Y 904

Chain	Residue
2	HIS10
4	HIS10
Y	HIS10
Y	ZN804

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SCN B 905

Chain	Residue
B	HIS10
B	ZN801
F	HIS10
J	HIS10

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SCN D 906

Chain	Residue
D	HIS10
D	ZN802
H	HIS10
L	HIS10

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO U 1001

Chain	Residue
R	HIS5
U	CYS6
U	SER9
U	ILE10
U	CYS11
U	HOH1003
V	LEU11
Y	LEU17

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO G 1002

Chain	Residue
B	LEU17
D	HIS5
G	CYS6
G	ILE10
G	CYS11
G	HOH1018
H	LEU11
H	ALA14

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO Q 1003

Chain	Residue
2	LEU17
Q	CYS6
Q	SER9
Q	ILE10
Q	CYS11
Q	HOH1021
R	LEU11
R	ALA14
T	HIS5

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO K 1004

Chain	Residue
F	LEU17
H	HIS5
K	CYS6
K	ILE10
K	CYS11
K	HOH1005
L	LEU11
L	ALA14

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RCO e 1005

Chain	Residue
d	HIS5
e	CYS6
e	ILE10
e	CYS11
e	HOH1010
f	LEU11
f	ALA14
h	LEU17

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO 3 1006

Chain	Residue
T	LEU17
2	HIS5
3	CYS6
3	SER9
3	ILE10
3	CYS11
3	HOH1018
4	LEU11
4	ALA14

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO 1 1007

Chain	Residue
1	CYS6
1	SER9
1	ILE10
1	CYS11
1	HOH1011
2	LEU11
2	ALA14
R	LEU17
Y	HIS5

site_id	CC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO S 1008

Chain	Residue
4	LEU17
S	CYS6
S	SER9
S	ILE10
S	CYS11
S	HOH1016
S	HOH1025
T	LEU11
T	ALA14

site_id	CC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE RCO C 1009

Chain	Residue
C	CYS6
C	SER9
C	ILE10
C	CYS11
C	HOH1010
D	LEU11
D	ALA14
J	LEU17
L	HIS5
L	HOH33

site_id	CC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO g 1010

Chain	Residue
f	LEU17
g	CYS6
g	SER9
g	ILE10
g	CYS11
g	HOH1016
h	LEU11
h	ALA14
j	HIS5

site_id	CC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO A 1011

Chain	Residue
A	CYS6
A	SER9
A	ILE10
A	CYS11
A	HOH1033
B	LEU11
B	ALA14
F	HIS5
H	LEU17

site_id	CC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO c 1012

Chain	Residue
b	HIS5
c	CYS6
c	SER9
c	ILE10
c	CYS11
c	HOH1016
d	LEU11
d	ALA14
l	LEU17

site_id	CC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO I 1013

Chain	Residue
B	HIS5
D	LEU17
I	CYS6
I	SER9
I	ILE10
I	CYS11
I	HOH1018
J	LEU11
J	ALA14

site_id	CC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO E 1014

Chain	Residue
E	CYS6
E	SER9
E	ILE10
E	CYS11
E	HOH1017
F	LEU11
F	ALA14
J	HIS5
L	LEU17

site_id	CC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE RCO X 1015

Chain	Residue
4	HIS5
V	LEU17
X	CYS6
X	SER9
X	ILE10
X	CYS11
X	HOH1016
X	HOH1034
Y	LEU11
Y	ALA14

site_id	DC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE RCO a 1016

Chain	Residue
a	CYS6
a	SER9
a	ILE10
a	CYS11
a	LEU16
a	HOH1018
b	LEU11
b	ALA14
f	HIS5
j	LEU17

site_id	DC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO k 1017

Chain	Residue
d	LEU17
h	HIS5
k	CYS6
k	SER9
k	ILE10
k	CYS11
k	HOH1019
l	LEU11
l	ALA14

site_id	DC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RCO i 1018

Chain	Residue
b	LEU17
i	CYS6
i	SER9
i	ILE10
i	CYS11
i	HOH1021
j	LEU11
j	ALA14
l	HIS5

site_id	DC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL T 1101

Chain	Residue
Q	THR8
Q	SER9
T	PHE1
T	HOH1104
T	HOH1113
T	HOH1117
T	HOH1125
T	HOH1132
c	ASN18

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCTSiCSlyqLenyC

Chain	Residue	Details
A	CYS6-CYS20

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	Peptide: {"description":"Insulin A chain","featureId":"PRO_0000015821"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	87
Details	Peptide: {"description":"Insulin B chain","featureId":"PRO_0000015819"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)