2OLW
Crystal Structure of E. coli pseudouridine synthase RluE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000455 | biological_process | enzyme-directed rRNA pseudouridine synthesis |
| A | 0001522 | biological_process | pseudouridine synthesis |
| A | 0003723 | molecular_function | RNA binding |
| A | 0006364 | biological_process | rRNA processing |
| A | 0009451 | biological_process | RNA modification |
| A | 0009982 | molecular_function | pseudouridine synthase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016866 | molecular_function | intramolecular transferase activity |
| A | 0120159 | molecular_function | rRNA pseudouridine synthase activity |
| A | 0140098 | molecular_function | catalytic activity, acting on RNA |
| A | 0160137 | molecular_function | 23S rRNA pseudouridine(2457) synthase activity |
| B | 0000455 | biological_process | enzyme-directed rRNA pseudouridine synthesis |
| B | 0001522 | biological_process | pseudouridine synthesis |
| B | 0003723 | molecular_function | RNA binding |
| B | 0006364 | biological_process | rRNA processing |
| B | 0009451 | biological_process | RNA modification |
| B | 0009982 | molecular_function | pseudouridine synthase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016866 | molecular_function | intramolecular transferase activity |
| B | 0120159 | molecular_function | rRNA pseudouridine synthase activity |
| B | 0140098 | molecular_function | catalytic activity, acting on RNA |
| B | 0160137 | molecular_function | 23S rRNA pseudouridine(2457) synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1001 |
| Chain | Residue |
| A | GLN53 |
| A | PHE54 |
| A | THR55 |
| A | THR130 |
| A | HIS186 |
| A | HOH1011 |
| A | HOH1014 |
| A | HOH1018 |
| A | HOH1051 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DTT B 218 |
| Chain | Residue |
| A | ARG40 |
| A | PRO68 |
| A | VAL69 |
| A | TRP212 |
| A | GLU214 |
| B | LEU51 |
| B | ARG60 |
| B | ARG80 |
| B | HOH1045 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY B 1002 |
| Chain | Residue |
| B | LEU204 |
| B | ASN206 |
| B | HOH1083 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY B 1003 |
| Chain | Residue |
| B | GLN53 |
| B | PHE54 |
| B | THR55 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACY A 1004 |
| Chain | Residue |
| A | LEU131 |
| A | ASN132 |
| A | ARG182 |
| A | HOH1022 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY A 1005 |
| Chain | Residue |
| A | TYR197 |
| A | ASN206 |
| A | HOH1073 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY B 1006 |
| Chain | Residue |
| B | LYS61 |
| B | GLY102 |
| B | ARG104 |
| B | THR105 |
| B | HOH1113 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACY B 1007 |
| Chain | Residue |
| A | ARG97 |
| B | ASP145 |
| B | GLU146 |
| B | HOH1147 |
Functional Information from PROSITE/UniProt
| site_id | PS01149 |
| Number of Residues | 15 |
| Details | PSI_RSU Rsu family of pseudouridine synthase signature. GRLDrdSeGLLVLTN |
| Chain | Residue | Details |
| A | GLY76-ASN90 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"17320904","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
