2OL0

High Resolution Crystal Structures of Vaccinia Virus dUTPase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004170	molecular_function	dUTP diphosphatase activity
A	0006226	biological_process	dUMP biosynthetic process
A	0009117	biological_process	nucleotide metabolic process
A	0016787	molecular_function	hydrolase activity
A	0046081	biological_process	dUTP catabolic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004170	molecular_function	dUTP diphosphatase activity
B	0006226	biological_process	dUMP biosynthetic process
B	0009117	biological_process	nucleotide metabolic process
B	0016787	molecular_function	hydrolase activity
B	0046081	biological_process	dUTP catabolic process
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004170	molecular_function	dUTP diphosphatase activity
C	0006226	biological_process	dUMP biosynthetic process
C	0009117	biological_process	nucleotide metabolic process
C	0016787	molecular_function	hydrolase activity
C	0046081	biological_process	dUTP catabolic process
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 300

Chain	Residue
A	GLN118
B	ARG65
B	GLN118
C	TYR63
C	GLN118

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 500

Chain	Residue
B	GLN25
B	HOH1233
C	DUD1203
C	HOH1229

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE DUD C 1201

Chain	Residue
A	GLY82
A	VAL83
A	ILE84
A	ASP85
A	TYR88
A	GLY93
C	ARG69
C	SER70
C	GLY71
C	ARG111
C	HOH1207
C	HOH1276

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DUD B 1202

Chain	Residue
A	ARG69
A	SER70
A	GLY71
A	ARG111
A	HOH360
B	GLY82
B	VAL83
B	ILE84
B	ASP85
B	TYR88
B	GLY93
B	ILE95
B	HOH1203

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE DUD C 1203

Chain	Residue
B	ARG69
B	SER70
B	GLY71
B	EDO403
B	MG500
C	GLY82
C	VAL83
C	ILE84
C	ASP85
C	TYR88
C	GLY93
C	ILE95
C	EDO401
C	HOH1208
C	HOH1242
C	HOH1269

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO C 401

Chain	Residue
B	SER26
C	ASP85
C	ASP87
C	TYR88
C	DUD1203

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 402

Chain	Residue
A	GLN118
A	ARG119
B	GLN118
B	ARG119
C	GLN118
C	ARG119

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 403

Chain	Residue
B	SER70
B	HOH1251
B	HOH1255
C	LEU49
C	GLY93
C	DUD1203

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	BINDING: BINDING => ECO:0000269|PubMed:17452782, ECO:0007744|PDB:2OKD

Chain	Residue	Details
A	ARG24
B	GLY82
B	TYR88
B	GLY93
B	ILE95
B	ARG111
C	ARG24
C	PRO68
C	GLY82
C	TYR88
C	GLY93
A	PRO68
C	ILE95
C	ARG111
A	GLY82
A	TYR88
A	GLY93
A	ILE95
A	ARG111
B	ARG24
B	PRO68

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
A	ASP85
A	ASP87

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
B	ASP85
B	ASP87

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1dup

Chain	Residue	Details
C	ASP85
C	ASP87

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