2OJU
X-ray structure of complex of human cyclophilin J with cyclosporin A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000398 | biological_process | mRNA splicing, via spliceosome |
| A | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005681 | cellular_component | spliceosomal complex |
| A | 0006397 | biological_process | mRNA processing |
| A | 0006457 | biological_process | protein folding |
| A | 0008380 | biological_process | RNA splicing |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0071013 | cellular_component | catalytic step 2 spliceosome |
| B | 0000398 | biological_process | mRNA splicing, via spliceosome |
| B | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| B | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005681 | cellular_component | spliceosomal complex |
| B | 0006397 | biological_process | mRNA processing |
| B | 0006457 | biological_process | protein folding |
| B | 0008380 | biological_process | RNA splicing |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0071013 | cellular_component | catalytic step 2 spliceosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR CHAIN C OF CYCLOSPORIN A |
| Chain | Residue |
| A | GLU32 |
| A | ASN98 |
| A | GLN106 |
| A | PHE108 |
| A | HIS116 |
| A | TYR121 |
| A | PRO164 |
| A | HOH2003 |
| B | SER1 |
| B | VAL3 |
| C | HOH2001 |
| A | ALA36 |
| A | ALA39 |
| A | ARG50 |
| A | PHE55 |
| A | GLN58 |
| A | GLY66 |
| A | ALA96 |
| A | ASN97 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR CHAIN D OF CYCLOSPORIN A |
| Chain | Residue |
| B | LEU35 |
| B | ALA36 |
| B | ALA39 |
| B | SER40 |
| B | ARG50 |
| B | PHE55 |
| B | GLN58 |
| B | GLY66 |
| B | ARG67 |
| B | ALA96 |
| B | ASN97 |
| B | ASN98 |
| B | GLN106 |
| B | PHE108 |
| B | HIS116 |
| B | TYR121 |
| B | HOH2004 |
Functional Information from PROSITE/UniProt
| site_id | PS00170 |
| Number of Residues | 18 |
| Details | CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YngCiFHRNIkgFMvQTG |
| Chain | Residue | Details |
| A | TYR43-GLY60 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | SER8 | |
| B | SER8 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q9D6L8 |
| Chain | Residue | Details |
| A | ARG67 | |
| B | ARG67 |
