2OIZ

Crystal Structure of the Tryptamine-Derived (Indol-3-Acetamide)-TTQ Adduct of Aromatic Amine Dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0030058	molecular_function	aliphatic amine dehydrogenase activity
A	0030059	molecular_function	aralkylamine dehydrogenase (azurin) activity
A	0042597	cellular_component	periplasmic space
B	0016491	molecular_function	oxidoreductase activity
B	0030058	molecular_function	aliphatic amine dehydrogenase activity
B	0030059	molecular_function	aralkylamine dehydrogenase (azurin) activity
B	0042597	cellular_component	periplasmic space
D	0009308	biological_process	amine metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016638	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors
D	0030059	molecular_function	aralkylamine dehydrogenase (azurin) activity
D	0042597	cellular_component	periplasmic space
H	0009308	biological_process	amine metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016638	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors
H	0030059	molecular_function	aralkylamine dehydrogenase (azurin) activity
H	0042597	cellular_component	periplasmic space

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TSR D 1702

Chain	Residue
B	PHE97
D	TRP160
D	PHE169
D	THR172
B	LEU100
B	GLY178
D	ASP84
D	TRQ109
D	ASP128
D	ASN156
D	VAL158
D	ASN159

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TSR H 1701

Chain	Residue
A	PHE97
A	LEU100
A	GLY178
H	ASP84
H	TRQ109
H	ASP128
H	ASN156
H	VAL158
H	ASN159
H	TRP160
H	PHE169

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 A 1700

Chain	Residue
A	HOH1854
A	HOH1883
A	HOH1904
A	HOH2159
A	HOH2260

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:16614214, ECO:0000269|PubMed:17005560, ECO:0000269|PubMed:17087503

Chain	Residue	Details
A	ALA122
A	GLY125
A	GLY149
B	ALA122
B	GLY125
B	GLY149

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:16279953

Chain	Residue	Details
A	ASP94
B	ASP94

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16614214, ECO:0000269|PubMed:17005560

Chain	Residue	Details
D	ASP84
D	ASN156
H	ASP84
H	ASN156

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Transition state stabilizer

Chain	Residue	Details
D	THR172
H	THR172

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Tryptophylquinone => ECO:0000269|PubMed:16614214, ECO:0000269|PubMed:17005560, ECO:0000269|PubMed:17087503

Chain	Residue	Details
D	TRQ109
H	TRQ109

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Tryptophan tryptophylquinone (Trp-Trp) => ECO:0000269|PubMed:16614214, ECO:0000269|PubMed:17005560, ECO:0000269|PubMed:17087503

Chain	Residue	Details
D	TRQ109
D	TRP160
H	TRQ109
H	TRP160

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 2bbk

Chain	Residue	Details
D	THR172
D	ASP84
D	PHE169
D	TRP160
D	ASP128

---

site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 2bbk

Chain	Residue	Details
H	THR172
H	ASP84
H	PHE169
H	TRP160
H	ASP128

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