2OEC
Crystal structure of the uridine phosphorylase from Salmonella typhimurium in complex with 2,2'-anhydrouridine and potassium ion at 2.194A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0044206 | biological_process | UMP salvage |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0044206 | biological_process | UMP salvage |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0009166 | biological_process | nucleotide catabolic process |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0044206 | biological_process | UMP salvage |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0009166 | biological_process | nucleotide catabolic process |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0044206 | biological_process | UMP salvage |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009164 | biological_process | nucleoside catabolic process |
| E | 0009166 | biological_process | nucleotide catabolic process |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0044206 | biological_process | UMP salvage |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009164 | biological_process | nucleoside catabolic process |
| F | 0009166 | biological_process | nucleotide catabolic process |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0044206 | biological_process | UMP salvage |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 501 |
| Chain | Residue |
| C | GLU1049 |
| C | ILE1069 |
| C | SER1073 |
| D | GLU1049 |
| D | ILE1069 |
| D | SER1073 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K E 502 |
| Chain | Residue |
| F | GLU1049 |
| F | ILE1069 |
| F | SER1073 |
| E | GLU1049 |
| E | ILE1069 |
| E | SER1073 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 503 |
| Chain | Residue |
| A | GLU1049 |
| A | ILE1069 |
| A | SER1073 |
| B | GLU1049 |
| B | ILE1069 |
| B | SER1073 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ANU B 2 |
| Chain | Residue |
| A | HIS1008 |
| B | ILE1069 |
| B | THR1094 |
| B | GLY1096 |
| B | GLN1166 |
| B | GLU1196 |
| B | MET1197 |
| B | GLU1198 |
| B | HOH1296 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ANU F 6 |
| Chain | Residue |
| E | HIS1008 |
| F | GOL16 |
| F | THR1094 |
| F | PHE1162 |
| F | GLN1166 |
| F | ARG1168 |
| F | GLU1196 |
| F | MET1197 |
| F | GLU1198 |
| F | HOH1264 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1PE B 62 |
| Chain | Residue |
| B | SER1004 |
| B | ASP1005 |
| B | ARG1168 |
| B | VAL1221 |
| B | ASN1222 |
| B | ARG1223 |
| B | GLN1225 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE 1PE D 314 |
| Chain | Residue |
| D | ARG1178 |
| D | LYS1181 |
| D | HOH1293 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 1PE B 315 |
| Chain | Residue |
| B | ARG1178 |
| B | LYS1181 |
| B | HOH1298 |
| C | ARG1178 |
| E | ARG1178 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL F 16 |
| Chain | Residue |
| E | ARG1048 |
| F | ANU6 |
| F | GLY1026 |
| F | ASP1027 |
| F | ARG1030 |
| F | ARG1091 |
| F | ILE1092 |
| F | GLY1093 |
| F | THR1094 |
| F | GLU1198 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| Chain | Residue | Details |
| A | SER1066-LEU1081 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| A | ARG1223 | |
| A | GLU1080 | |
| A | HIS1008 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| B | ARG1223 | |
| B | GLU1080 | |
| B | HIS1008 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| C | ARG1223 | |
| C | GLU1080 | |
| C | HIS1008 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| D | ARG1223 | |
| D | GLU1080 | |
| D | HIS1008 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| E | ARG1223 | |
| E | GLU1080 | |
| E | HIS1008 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| F | ARG1223 | |
| F | GLU1080 | |
| F | HIS1008 |
