Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2OBX

Lumazine synthase RibH2 from Mesorhizobium loti (Gene mll7281, Swiss-Prot entry Q986N2) complexed with inhibitor 5-Nitro-6-(D-Ribitylamino)-2,4(1H,3H) Pyrimidinedione

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
A	0005829	cellular_component	cytosol
A	0009231	biological_process	riboflavin biosynthetic process
A	0009349	cellular_component	riboflavin synthase complex
A	0016740	molecular_function	transferase activity
B	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
B	0005829	cellular_component	cytosol
B	0009231	biological_process	riboflavin biosynthetic process
B	0009349	cellular_component	riboflavin synthase complex
B	0016740	molecular_function	transferase activity
C	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
C	0005829	cellular_component	cytosol
C	0009231	biological_process	riboflavin biosynthetic process
C	0009349	cellular_component	riboflavin synthase complex
C	0016740	molecular_function	transferase activity
D	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
D	0005829	cellular_component	cytosol
D	0009231	biological_process	riboflavin biosynthetic process
D	0009349	cellular_component	riboflavin synthase complex
D	0016740	molecular_function	transferase activity
E	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
E	0005829	cellular_component	cytosol
E	0009231	biological_process	riboflavin biosynthetic process
E	0009349	cellular_component	riboflavin synthase complex
E	0016740	molecular_function	transferase activity
F	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
F	0005829	cellular_component	cytosol
F	0009231	biological_process	riboflavin biosynthetic process
F	0009349	cellular_component	riboflavin synthase complex
F	0016740	molecular_function	transferase activity
G	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
G	0005829	cellular_component	cytosol
G	0009231	biological_process	riboflavin biosynthetic process
G	0009349	cellular_component	riboflavin synthase complex
G	0016740	molecular_function	transferase activity
H	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
H	0005829	cellular_component	cytosol
H	0009231	biological_process	riboflavin biosynthetic process
H	0009349	cellular_component	riboflavin synthase complex
H	0016740	molecular_function	transferase activity
I	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
I	0005829	cellular_component	cytosol
I	0009231	biological_process	riboflavin biosynthetic process
I	0009349	cellular_component	riboflavin synthase complex
I	0016740	molecular_function	transferase activity
J	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
J	0005829	cellular_component	cytosol
J	0009231	biological_process	riboflavin biosynthetic process
J	0009349	cellular_component	riboflavin synthase complex
J	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 1001

Chain	Residue
A	GLY83
A	GLY84
A	ILE85
A	TYR86

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 B 1002

Chain	Residue
B	GLY83
B	GLY84
B	ILE85
B	TYR86

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 C 1003

Chain	Residue
C	GLY84
C	ILE85
C	TYR86
C	GLY83

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 E 1004

Chain	Residue
E	GLY83
E	GLY84
E	ILE85
E	TYR86

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 F 1005

Chain	Residue
F	VAL81
F	ASN82
F	GLY83
F	GLY84
F	ILE85
F	TYR86
F	ARG87
F	HIS88
F	INI206

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 G 1006

Chain	Residue
G	ASN82
G	GLY83
G	GLY84
G	ILE85
G	TYR86

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 I 1007

Chain	Residue
I	ASN82
I	GLY83
I	GLY84
I	ILE85
I	TYR86
I	HOH505

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 J 1008

Chain	Residue
J	GLY83
J	GLY84
J	ILE85
J	TYR86

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 J 1009

Chain	Residue
J	ARG18
J	ARG18

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE INI A 201

Chain	Residue
A	TRP21
A	GLY54
A	ALA55
A	TYR56
A	GLU57
A	PHE79
A	VAL80
A	VAL81
E	LEU111
E	SER112

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE INI B 202

Chain	Residue
A	LEU111
A	SER112
B	TRP21
B	GLY54
B	ALA55
B	TYR56
B	GLU57
B	PHE79
B	VAL80
B	VAL81
B	HOH321

site_id	BC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE INI C 203

Chain	Residue
B	LEU111
B	SER112
C	TRP21
C	GLY54
C	ALA55
C	TYR56
C	GLU57
C	PHE79
C	VAL80
C	VAL81
C	HOH331
C	HOH342
C	HOH343
C	HOH473

site_id	BC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE INI D 204

Chain	Residue
C	LEU111
C	SER112
D	ALA19
D	TRP21
D	GLY54
D	ALA55
D	TYR56
D	GLU57
D	PHE79
D	VAL80
D	VAL81

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE INI E 205

Chain	Residue
D	LEU111
D	SER112
E	TRP21
E	GLY54
E	ALA55
E	TYR56
E	GLU57
E	PHE79
E	VAL80
E	VAL81

site_id	BC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE INI F 206

Chain	Residue
F	HIS22
F	GLY54
F	ALA55
F	TYR56
F	GLU57
F	PHE79
F	VAL80
F	VAL81
F	PO41005
J	LEU111
J	SER112
F	TRP21

site_id	BC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE INI G 207

Chain	Residue
F	LEU111
F	SER112
G	TRP21
G	GLY54
G	ALA55
G	TYR56
G	GLU57
G	PHE79
G	VAL80
G	VAL81
G	HOH403
G	HOH407

site_id	BC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE INI H 208

Chain	Residue
G	LEU111
G	SER112
H	ALA19
H	TRP21
H	GLY54
H	ALA55
H	TYR56
H	GLU57
H	PHE79
H	VAL80
H	VAL81

site_id	BC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE INI I 209

Chain	Residue
H	LEU111
H	SER112
I	ALA19
I	TRP21
I	GLY54
I	ALA55
I	TYR56
I	GLU57
I	PHE79
I	VAL80
I	VAL81
I	HOH442

site_id	CC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE INI J 210

Chain	Residue
I	LEU111
I	SER112
J	TRP21
J	GLY54
J	ALA55
J	TYR56
J	GLU57
J	PHE79
J	VAL80
J	VAL81
J	HOH458

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
A	ARG87

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
B	ARG87

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
C	ARG87

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
D	ARG87

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
E	ARG87

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
F	ARG87

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
G	ARG87

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
H	ARG87

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
I	ARG87

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1rvv

Chain	Residue	Details
J	ARG87

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)