2OBI

Crystal structure of the Selenocysteine to Cysteine Mutant of human phospholipid hydroperoxide glutathione peroxidase (GPx4)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0006979	biological_process	response to oxidative stress

Functional Information from PROSITE/UniProt

site_id	PS00460
Number of Residues	16
Details	GLUTATHIONE_PEROXID_1 Glutathione peroxidases active site. GFvCIVtNVaSqCGkT

Chain	Residue	Details
A	GLY34-THR49

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site_id	PS00763
Number of Residues	8
Details	GLUTATHIONE_PEROXID_2 Glutathione peroxidases signature 2. LAFPCNQF

Chain	Residue	Details
A	LEU71-PHE78

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"O70325","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Non-standard residue: {"description":"Selenocysteine","evidences":[{"source":"PubMed","id":"8039723","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"9705830","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P36970","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1gp1

Chain	Residue	Details
A	GLN81
A	TRP136

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