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2OAU

Mechanosensitive Channel of Small Conductance (MscS)

Replaces:  1MXM
Functional Information from GO Data
ChainGOidnamespacecontents
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0008381molecular_functionmechanosensitive monoatomic ion channel activity
A0009992biological_processintracellular water homeostasis
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0051260biological_processprotein homooligomerization
A0055085biological_processtransmembrane transport
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0008381molecular_functionmechanosensitive monoatomic ion channel activity
B0009992biological_processintracellular water homeostasis
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0051260biological_processprotein homooligomerization
B0055085biological_processtransmembrane transport
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0008381molecular_functionmechanosensitive monoatomic ion channel activity
C0009992biological_processintracellular water homeostasis
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0051260biological_processprotein homooligomerization
C0055085biological_processtransmembrane transport
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0008381molecular_functionmechanosensitive monoatomic ion channel activity
D0009992biological_processintracellular water homeostasis
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0008381molecular_functionmechanosensitive monoatomic ion channel activity
E0009992biological_processintracellular water homeostasis
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
E0042802molecular_functionidentical protein binding
E0051260biological_processprotein homooligomerization
E0055085biological_processtransmembrane transport
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0008381molecular_functionmechanosensitive monoatomic ion channel activity
F0009992biological_processintracellular water homeostasis
F0016020cellular_componentmembrane
F0034220biological_processmonoatomic ion transmembrane transport
F0042802molecular_functionidentical protein binding
F0051260biological_processprotein homooligomerization
F0055085biological_processtransmembrane transport
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0008381molecular_functionmechanosensitive monoatomic ion channel activity
G0009992biological_processintracellular water homeostasis
G0016020cellular_componentmembrane
G0034220biological_processmonoatomic ion transmembrane transport
G0042802molecular_functionidentical protein binding
G0051260biological_processprotein homooligomerization
G0055085biological_processtransmembrane transport
Functional Information from PROSITE/UniProt
site_idPS01246
Number of Residues35
DetailsUPF0003 Uncharacterized protein family UPF0003 signature. GTVlsVqifsttMrtaDgkiIvIPNgkIIagniiN
ChainResidueDetails
AGLY143-ASN177

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues210
DetailsTOPO_DOM: Periplasmic => ECO:0000305|PubMed:15919996
ChainResidueDetails
AMET1-ASN30
EVAL89-GLY90
FMET1-ASN30
FVAL89-GLY90
GMET1-ASN30
GVAL89-GLY90
AVAL89-GLY90
BMET1-ASN30
BVAL89-GLY90
CMET1-ASN30
CVAL89-GLY90
DMET1-ASN30
DVAL89-GLY90
EMET1-ASN30

site_idSWS_FT_FI2
Number of Residues427
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:12446901, ECO:0000269|PubMed:26551077
ChainResidueDetails
AILE31-VAL52
DILE31-VAL52
DPHE68-ARG88
DVAL91-LEU111
EILE31-VAL52
EPHE68-ARG88
EVAL91-LEU111
FILE31-VAL52
FPHE68-ARG88
FVAL91-LEU111
GILE31-VAL52
APHE68-ARG88
GPHE68-ARG88
GVAL91-LEU111
AVAL91-LEU111
BILE31-VAL52
BPHE68-ARG88
BVAL91-LEU111
CILE31-VAL52
CPHE68-ARG88
CVAL91-LEU111

site_idSWS_FT_FI3
Number of Residues1316
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:15919996
ChainResidueDetails
AASN53-ASP67
EGLN112-ALA286
FASN53-ASP67
FGLN112-ALA286
GASN53-ASP67
GGLN112-ALA286
AGLN112-ALA286
BASN53-ASP67
BGLN112-ALA286
CASN53-ASP67
CGLN112-ALA286
DASN53-ASP67
DGLN112-ALA286
EASN53-ASP67

218853

PDB entries from 2024-04-24

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