2OA6
Aristolochene synthase from Aspergillus terreus complexed with pyrophosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0010333 | molecular_function | terpene synthase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| A | 0045483 | molecular_function | aristolochene synthase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0010333 | molecular_function | terpene synthase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| B | 0045483 | molecular_function | aristolochene synthase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0010333 | molecular_function | terpene synthase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| C | 0045483 | molecular_function | aristolochene synthase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0008299 | biological_process | isoprenoid biosynthetic process |
| D | 0010333 | molecular_function | terpene synthase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016838 | molecular_function | carbon-oxygen lyase activity, acting on phosphates |
| D | 0045483 | molecular_function | aristolochene synthase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG D 701 |
| Chain | Residue |
| D | ASP90 |
| D | MG703 |
| D | GOL2647 |
| D | POP4293 |
| D | HOH4297 |
| D | HOH4314 |
| D | HOH4315 |
| D | HOH4316 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 702 |
| Chain | Residue |
| D | SER223 |
| D | GLU227 |
| D | POP4293 |
| D | HOH4295 |
| D | ASN219 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 703 |
| Chain | Residue |
| D | ASP90 |
| D | MG701 |
| D | POP4293 |
| D | HOH4294 |
| D | HOH4296 |
| D | HOH4314 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME C 1270 |
| Chain | Residue |
| C | CYS25 |
| C | ARG62 |
| D | PRO27 |
| D | GLU30 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BME D 1271 |
| Chain | Residue |
| C | PRO27 |
| C | VAL29 |
| C | GLU30 |
| D | CYS25 |
| D | VAL29 |
| D | ARG62 |
| D | CYS65 |
| D | LEU66 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME D 1272 |
| Chain | Residue |
| D | ARG162 |
| D | MET166 |
| D | CYS242 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME A 1273 |
| Chain | Residue |
| A | CYS25 |
| A | ARG62 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE POP D 4293 |
| Chain | Residue |
| D | PHE87 |
| D | ASP90 |
| D | ARG175 |
| D | ASN219 |
| D | SER223 |
| D | LYS226 |
| D | GLU227 |
| D | ARG314 |
| D | TYR315 |
| D | MG701 |
| D | MG702 |
| D | MG703 |
| D | HOH4294 |
| D | HOH4296 |
| D | HOH4315 |
| D | HOH4316 |
| D | HOH4324 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D 2647 |
| Chain | Residue |
| D | ASP90 |
| D | LEU93 |
| D | GLU94 |
| D | GLN157 |
| D | ARG162 |
| D | GLY238 |
| D | MG701 |
| D | HOH4297 |
| D | HOH4314 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17261032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18385128","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17261032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18385128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3BNX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18385128","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3BNX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1di1 |
| Chain | Residue | Details |
| A | PHE87 | |
| A | TRP308 | |
| A | TYR67 | |
| A | PHE153 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1di1 |
| Chain | Residue | Details |
| B | PHE87 | |
| B | TRP308 | |
| B | TYR67 | |
| B | PHE153 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1di1 |
| Chain | Residue | Details |
| C | PHE87 | |
| C | TRP308 | |
| C | TYR67 | |
| C | PHE153 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1di1 |
| Chain | Residue | Details |
| D | PHE87 | |
| D | TRP308 | |
| D | TYR67 | |
| D | PHE153 |
