2O9K

WDR5 in Complex with Dimethylated H3K4 Peptide

Replaces:  2H9O

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000123	cellular_component	histone acetyltransferase complex
A	0001501	biological_process	skeletal system development
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006094	biological_process	gluconeogenesis
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0035064	molecular_function	methylated histone binding
A	0035097	cellular_component	histone methyltransferase complex
A	0042393	molecular_function	histone binding
A	0042800	molecular_function	histone H3K4 methyltransferase activity
A	0044545	cellular_component	NSL complex
A	0044665	cellular_component	MLL1/2 complex
A	0044666	cellular_component	MLL3/4 complex
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045815	biological_process	transcription initiation-coupled chromatin remodeling
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045995	biological_process	regulation of embryonic development
A	0048188	cellular_component	Set1C/COMPASS complex
A	0051302	biological_process	regulation of cell division
A	0051726	biological_process	regulation of cell cycle
A	0071339	cellular_component	MLL1 complex
A	0072686	cellular_component	mitotic spindle
A	0090043	biological_process	regulation of tubulin deacetylation
A	0140672	cellular_component	ATAC complex
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000123	cellular_component	histone acetyltransferase complex
C	0001501	biological_process	skeletal system development
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006094	biological_process	gluconeogenesis
C	0006325	biological_process	chromatin organization
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0035064	molecular_function	methylated histone binding
C	0035097	cellular_component	histone methyltransferase complex
C	0042393	molecular_function	histone binding
C	0042800	molecular_function	histone H3K4 methyltransferase activity
C	0044545	cellular_component	NSL complex
C	0044665	cellular_component	MLL1/2 complex
C	0044666	cellular_component	MLL3/4 complex
C	0045722	biological_process	positive regulation of gluconeogenesis
C	0045815	biological_process	transcription initiation-coupled chromatin remodeling
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0045995	biological_process	regulation of embryonic development
C	0048188	cellular_component	Set1C/COMPASS complex
C	0051302	biological_process	regulation of cell division
C	0051726	biological_process	regulation of cell cycle
C	0071339	cellular_component	MLL1 complex
C	0072686	cellular_component	mitotic spindle
C	0090043	biological_process	regulation of tubulin deacetylation
C	0140672	cellular_component	ATAC complex

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV

Chain	Residue	Details
A	LEU102-VAL116
A	ILE144-VAL158
A	ILE186-THR200
A	ILE274-LEU288

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Important for interaction with histone H3

Chain	Residue	Details
A	ASP107
A	PHE133
A	PHE263
A	GLU322
C	ASP107
C	PHE133
C	PHE263
C	GLU322

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS112
C	LYS112

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site_id	SWS_FT_FI3
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS27
A	LYS46
C	LYS27
C	LYS46

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1g72

Chain	Residue	Details
A	GLY73

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1g72

Chain	Residue	Details
A	ASP242

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site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1g72

Chain	Residue	Details
C	GLY73

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site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1g72

Chain	Residue	Details
C	ASP242

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