Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006833 | biological_process | water transport |
| A | 0006970 | biological_process | response to osmotic stress |
| A | 0009992 | biological_process | intracellular water homeostasis |
| A | 0015250 | molecular_function | water channel activity |
| A | 0015267 | molecular_function | channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG A 232 |
| Chain | Residue |
| A | HIS174 |
| A | SER184 |
| A | ASN186 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG A 233 |
| Chain | Residue |
| A | GLU138 |
| A | SER177 |
| A | VAL185 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG A 234 |
Functional Information from PROSITE/UniProt
| site_id | PS00221 |
| Number of Residues | 9 |
| Details | MIP MIP family signature. HFNPAVTIG |
| Chain | Residue | Details |
| A | HIS61-GLY69 | |
| site_id | PS00501 |
| Number of Residues | 8 |
| Details | SPASE_I_1 Signal peptidases I serine active site. GYSMLSAL |
| Chain | Residue | Details |
| A | GLY128-LEU135 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-GLU8 | |
| A | GLY55-VAL81 | |
| A | ALA152-LYS155 | |
| A | TYR223-ASP231 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | SER9-PHE29 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 54 |
| Details | TOPO_DOM: Periplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | PRO30-GLY33 | |
| A | ALA103-SER130 | |
| A | SER177-ALA201 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE34-VAL54 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL82-ILE102 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET131-GLY151 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE156-ILE176 | |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU202-ILE222 | |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | SITE: Involved in tetramerization or stability of the tetramer |
| Chain | Residue | Details |
| A | SER20 | |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | SITE: Selectivity filter |
| Chain | Residue | Details |
| A | PHE43 | |
| A | HIS174 | |
| A | CYS183 | |
| A | ARG189 | |
