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2O8T

Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q) in complex with Inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 402
ChainResidue
AILE47
ALEU123
AHOH5100

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 403
ChainResidue
AHOH5182
AHOH5196
AHOH5280
AHIS57
AGLN192
AGLY193
AASP194
ASER195
AHOH5138

site_idAC3
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 1PE A 314
ChainResidue
AASN74
ASER135
ACYS136
AGLU137
AVAL159
ASER202
AGLN204
AMET207
A1PE315
AHOH5203
AHOH5284

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE 1PE A 315
ChainResidue
AVAL38
ATHR39
AASN74
A1PE314
AHOH5143

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PEG A 5084
ChainResidue
AGLY133
ALEU162
AILE163
APRO185

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC
ChainResidueDetails
AILE53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
AASP102
ASER195

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:9151681
ChainResidueDetails
ASER146

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AGLN145

218853

PDB entries from 2024-04-24

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