Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2O8A

rat PP1cgamma complexed with mouse inhibitor-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000164	cellular_component	protein phosphatase type 1 complex
A	0000776	cellular_component	kinetochore
A	0000781	cellular_component	chromosome, telomeric region
A	0001824	biological_process	blastocyst development
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005521	molecular_function	lamin binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005815	cellular_component	microtubule organizing center
A	0005829	cellular_component	cytosol
A	0005977	biological_process	glycogen metabolic process
A	0006470	biological_process	protein dephosphorylation
A	0007283	biological_process	spermatogenesis
A	0008157	molecular_function	protein phosphatase 1 binding
A	0016607	cellular_component	nuclear speck
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0019901	molecular_function	protein kinase binding
A	0019903	molecular_function	protein phosphatase binding
A	0019904	molecular_function	protein domain specific binding
A	0030182	biological_process	neuron differentiation
A	0030496	cellular_component	midbody
A	0032154	cellular_component	cleavage furrow
A	0032922	biological_process	circadian regulation of gene expression
A	0032991	cellular_component	protein-containing complex
A	0042752	biological_process	regulation of circadian rhythm
A	0043153	biological_process	entrainment of circadian clock by photoperiod
A	0043197	cellular_component	dendritic spine
A	0044877	molecular_function	protein-containing complex binding
A	0046822	biological_process	regulation of nucleocytoplasmic transport
A	0046872	molecular_function	metal ion binding
A	0048511	biological_process	rhythmic process
A	0051301	biological_process	cell division
A	0060252	biological_process	positive regulation of glial cell proliferation
A	0072357	cellular_component	PTW/PP1 phosphatase complex
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
B	0000164	cellular_component	protein phosphatase type 1 complex
B	0000776	cellular_component	kinetochore
B	0000781	cellular_component	chromosome, telomeric region
B	0001824	biological_process	blastocyst development
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0005515	molecular_function	protein binding
B	0005521	molecular_function	lamin binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005815	cellular_component	microtubule organizing center
B	0005829	cellular_component	cytosol
B	0005977	biological_process	glycogen metabolic process
B	0006470	biological_process	protein dephosphorylation
B	0007283	biological_process	spermatogenesis
B	0008157	molecular_function	protein phosphatase 1 binding
B	0016607	cellular_component	nuclear speck
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0019901	molecular_function	protein kinase binding
B	0019903	molecular_function	protein phosphatase binding
B	0019904	molecular_function	protein domain specific binding
B	0030182	biological_process	neuron differentiation
B	0030496	cellular_component	midbody
B	0032154	cellular_component	cleavage furrow
B	0032922	biological_process	circadian regulation of gene expression
B	0032991	cellular_component	protein-containing complex
B	0042752	biological_process	regulation of circadian rhythm
B	0043153	biological_process	entrainment of circadian clock by photoperiod
B	0043197	cellular_component	dendritic spine
B	0044877	molecular_function	protein-containing complex binding
B	0046822	biological_process	regulation of nucleocytoplasmic transport
B	0046872	molecular_function	metal ion binding
B	0048511	biological_process	rhythmic process
B	0051301	biological_process	cell division
B	0060252	biological_process	positive regulation of glial cell proliferation
B	0072357	cellular_component	PTW/PP1 phosphatase complex
B	0098793	cellular_component	presynapse
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
I	0004864	molecular_function	protein phosphatase inhibitor activity
I	0005977	biological_process	glycogen metabolic process
I	0009966	biological_process	regulation of signal transduction
I	0019904	molecular_function	protein domain specific binding
I	0030426	cellular_component	growth cone
I	0035556	biological_process	intracellular signal transduction
I	0043197	cellular_component	dendritic spine
I	0140678	molecular_function	molecular function inhibitor activity
J	0004864	molecular_function	protein phosphatase inhibitor activity
J	0005977	biological_process	glycogen metabolic process
J	0009966	biological_process	regulation of signal transduction
J	0019904	molecular_function	protein domain specific binding
J	0030426	cellular_component	growth cone
J	0035556	biological_process	intracellular signal transduction
J	0043197	cellular_component	dendritic spine
J	0140678	molecular_function	molecular function inhibitor activity

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
A	LEU121-GLU126

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17636256","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	10
Details	Region: {"description":"Required for binding PPP1CC"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	24
Details	Region: {"description":"Required for binding the 'RVXF' binding groove of PPP1CC"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Region: {"description":"Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	22
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by ATM","evidences":[{"source":"UniProtKB","id":"P41236","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1aui

Chain	Residue	Details
A	ASP95
A	HIS125

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1aui

Chain	Residue	Details
B	ASP95
B	HIS125

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)