2O7S

Crystal Structure of the A. thaliana DHQ-dehydroshikimate-SDH-shikimate-NADP(H)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003855	molecular_function	3-dehydroquinate dehydratase activity
A	0004764	molecular_function	shikimate 3-dehydrogenase (NADP+) activity
A	0019632	biological_process	shikimate metabolic process
A	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1403

Chain	Residue
A	TRP158
A	SER334
A	PRO527
A	HOH9246

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DHK A 9241

Chain	Residue
A	PHE291
A	SER300
A	ALA301
A	GLN304
A	HOH9258
A	GLU124
A	ARG126
A	ARG155
A	LYS241
A	ARG279

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TLA A 1241

Chain	Residue
A	ARG155
A	HIS214
A	LYS241
A	LEU269
A	MET271
A	ARG279
A	PHE291
A	ALA301
A	GLN304
A	HOH9349

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DHK A 4733

Chain	Residue
A	ILE328
A	SER336
A	SER338
A	SER379
A	THR381
A	LYS385
A	ASN406
A	ASP423
A	TYR550
A	GLN578
A	GLN582
A	NAP1411
A	HOH9267

---

site_id	AC5
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NAP A 1411

Chain	Residue
A	ILE382
A	PRO383
A	LYS385
A	ASP423
A	GLY460
A	ALA461
A	GLY462
A	GLY463
A	ALA464
A	ASN483
A	ARG484
A	THR485
A	ARG488
A	THR520
A	THR521
A	SER522
A	MET523
A	MET525
A	ALA548
A	TYR550
A	GLY571
A	MET574
A	PHE575
A	GLN578
A	DHK4733
A	HOH9263
A	HOH9267
A	HOH9328

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor; for 3-dehydroquinate dehydratase activity => ECO:0000305|PubMed:16784230

Chain	Residue	Details
A	HIS214

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity => ECO:0000305|PubMed:16784230

Chain	Residue	Details
A	LYS241

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: For shikimate dehydrogenase activity => ECO:0000305|PubMed:16784230

Chain	Residue	Details
A	LYS385
A	ASP423

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|DOI:10.1021/cg7007107, ECO:0007744|PDB:2O7Q

Chain	Residue	Details
A	GLU124
A	ARG126
A	ARG155
A	LYS241
A	ARG279
A	SER300
A	GLN304

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:16784230, ECO:0007744|PDB:2GPT

Chain	Residue	Details
A	SER336
A	SER338
A	THR381
A	LYS385
A	ASN406
A	ASP423
A	TYR550
A	GLN578
A	GLN582

---

site_id	SWS_FT_FI6
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|DOI:10.1021/cg7007107, ECO:0007744|PDB:2O7S

Chain	Residue	Details
A	ALA461
A	GLY463
A	ALA464
A	ASN483
A	THR485
A	ARG488
A	MET525
A	ALA548
A	GLY571

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1qfe

Chain	Residue	Details
A	LYS241
A	HIS214
A	GLU159

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1qfe

Chain	Residue	Details
A	ASP414

---