Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2O7E

Tyrosine ammonia-lyase from Rhodobacter sphaeroides (His89Phe variant), bound to 2-aminoindan-2-phosphonic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0006572	biological_process	L-tyrosine catabolic process
A	0009698	biological_process	phenylpropanoid metabolic process
A	0009699	biological_process	phenylpropanoid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016841	molecular_function	ammonia-lyase activity
A	0042802	molecular_function	identical protein binding
A	0044550	biological_process	secondary metabolite biosynthetic process
A	0051289	biological_process	protein homotetramerization
A	0052883	molecular_function	tyrosine ammonia-lyase activity
B	0003824	molecular_function	catalytic activity
B	0006572	biological_process	L-tyrosine catabolic process
B	0009698	biological_process	phenylpropanoid metabolic process
B	0009699	biological_process	phenylpropanoid biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016841	molecular_function	ammonia-lyase activity
B	0042802	molecular_function	identical protein binding
B	0044550	biological_process	secondary metabolite biosynthetic process
B	0051289	biological_process	protein homotetramerization
B	0052883	molecular_function	tyrosine ammonia-lyase activity
C	0003824	molecular_function	catalytic activity
C	0006572	biological_process	L-tyrosine catabolic process
C	0009698	biological_process	phenylpropanoid metabolic process
C	0009699	biological_process	phenylpropanoid biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016841	molecular_function	ammonia-lyase activity
C	0042802	molecular_function	identical protein binding
C	0044550	biological_process	secondary metabolite biosynthetic process
C	0051289	biological_process	protein homotetramerization
C	0052883	molecular_function	tyrosine ammonia-lyase activity
D	0003824	molecular_function	catalytic activity
D	0006572	biological_process	L-tyrosine catabolic process
D	0009698	biological_process	phenylpropanoid metabolic process
D	0009699	biological_process	phenylpropanoid biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016841	molecular_function	ammonia-lyase activity
D	0042802	molecular_function	identical protein binding
D	0044550	biological_process	secondary metabolite biosynthetic process
D	0051289	biological_process	protein homotetramerization
D	0052883	molecular_function	tyrosine ammonia-lyase activity
E	0003824	molecular_function	catalytic activity
E	0006572	biological_process	L-tyrosine catabolic process
E	0009698	biological_process	phenylpropanoid metabolic process
E	0009699	biological_process	phenylpropanoid biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016841	molecular_function	ammonia-lyase activity
E	0042802	molecular_function	identical protein binding
E	0044550	biological_process	secondary metabolite biosynthetic process
E	0051289	biological_process	protein homotetramerization
E	0052883	molecular_function	tyrosine ammonia-lyase activity
F	0003824	molecular_function	catalytic activity
F	0006572	biological_process	L-tyrosine catabolic process
F	0009698	biological_process	phenylpropanoid metabolic process
F	0009699	biological_process	phenylpropanoid biosynthetic process
F	0016829	molecular_function	lyase activity
F	0016841	molecular_function	ammonia-lyase activity
F	0042802	molecular_function	identical protein binding
F	0044550	biological_process	secondary metabolite biosynthetic process
F	0051289	biological_process	protein homotetramerization
F	0052883	molecular_function	tyrosine ammonia-lyase activity
G	0003824	molecular_function	catalytic activity
G	0006572	biological_process	L-tyrosine catabolic process
G	0009698	biological_process	phenylpropanoid metabolic process
G	0009699	biological_process	phenylpropanoid biosynthetic process
G	0016829	molecular_function	lyase activity
G	0016841	molecular_function	ammonia-lyase activity
G	0042802	molecular_function	identical protein binding
G	0044550	biological_process	secondary metabolite biosynthetic process
G	0051289	biological_process	protein homotetramerization
G	0052883	molecular_function	tyrosine ammonia-lyase activity
H	0003824	molecular_function	catalytic activity
H	0006572	biological_process	L-tyrosine catabolic process
H	0009698	biological_process	phenylpropanoid metabolic process
H	0009699	biological_process	phenylpropanoid biosynthetic process
H	0016829	molecular_function	lyase activity
H	0016841	molecular_function	ammonia-lyase activity
H	0042802	molecular_function	identical protein binding
H	0044550	biological_process	secondary metabolite biosynthetic process
H	0051289	biological_process	protein homotetramerization
H	0052883	molecular_function	tyrosine ammonia-lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PMI A 701

Chain	Residue
A	TYR60
D	ARG303
A	MDO149
A	ASN203
A	ASN333
A	PHE350
A	HOH4925
B	MET405
D	GLN297
D	TYR300

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PMI B 701

Chain	Residue
A	MET405
B	TYR60
B	MDO149
B	ASN203
B	ASN333
B	PHE350
B	HOH4929
C	GLN297
C	TYR300
C	ARG303

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PMI C 701

Chain	Residue
B	GLN297
B	TYR300
B	ARG303
C	TYR60
C	MDO149
C	LEU153
C	ASN203
C	ASN333
C	PHE350
C	HOH3002
C	HOH4922
D	MET405

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PMI D 701

Chain	Residue
A	GLN297
A	TYR300
A	ARG303
C	MET405
D	TYR60
D	MDO149
D	ASN203
D	ASN333
D	PHE350
D	HOH4926

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PMI E 701

Chain	Residue
E	TYR60
E	MDO149
E	ASN203
E	ASN333
E	PHE350
E	HOH4923
F	MET405
H	GLN297
H	TYR300
H	ARG303

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PMI F 701

Chain	Residue
E	MET405
F	TYR60
F	MDO149
F	ASN203
F	ASN333
F	PHE350
F	HOH4924
G	GLN297
G	TYR300
G	ARG303

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PMI G 701

Chain	Residue
F	GLN297
F	TYR300
F	ARG303
G	TYR60
G	MDO149
G	LEU153
G	ASN203
G	ASN333
G	PHE350
G	HOH4921
H	MET405

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PMI H 701

Chain	Residue
E	GLN297
E	TYR300
E	ARG303
G	MET405
H	TYR60
H	MDO149
H	ASN203
H	ASN333
H	PHE350
H	HOH4930

Functional Information from PROSITE/UniProt

site_id	PS00488
Number of Residues	17
Details	PAL_HISTIDASE Phenylalanine and histidine ammonia-lyases signature. GTVGASGDLtPLAhmvL

Chain	Residue	Details
A	GLY145-LEU163

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	48
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"2,3-didehydroalanine (Ser)","evidences":[{"source":"PubMed","id":"17185228","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	16
Details	Cross-link: {"description":"5-imidazolinone (Ala-Gly)","evidences":[{"source":"PubMed","id":"17185228","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)