Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2O5Z

Crystal structure of the 1E9 LeuH47Trp/ArgH100Trp Fab 5-beta-androstane-3,17-dione complex

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 L 302

Chain	Residue
L	PRO8
L	LEU9
L	SER10
L	SER156

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 L 304

Chain	Residue
L	GLN27
L	SER27

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 305

Chain	Residue
L	ASP60
L	LYS188
L	SER52
L	ASN53
L	ARG54

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 L 308

Chain	Residue
L	HIS93
L	PHE94

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 L 311

Chain	Residue
H	LYS13
H	SER115
H	HOH360
L	SER202

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 312

Chain	Residue
L	PRO59
L	ARG61
L	GLU81

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 L 314

Chain	Residue
H	GLN105
L	GLN42
L	SER43
L	LYS45
L	HOH390
L	HOH401
L	HOH402

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 316

Chain	Residue
H	GLU56
H	SER57
L	ARG211

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 L 319

Chain	Residue
H	GLY169
H	HIS172
H	SO4317
L	ASN138
L	ASP170
L	HOH350

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 L 322

Chain	Residue
L	SER114
L	ASN138
L	HOH327
L	HOH407

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 H 301

Chain	Residue
H	TYR27
H	TYR27
H	MET28
H	MET28
H	TYR32
H	TYR32
H	HOH337

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 303

Chain	Residue
H	GLN179
H	SER180
H	HOH357
L	GLN160

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 306

Chain	Residue
H	VAL2
H	MET28
H	ASN31
H	ARG94
H	TYR102

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 H 307

Chain	Residue
H	ASN84
H	SER112
H	SER113
H	HOH327
H	HOH344
H	HOH398
L	ARG108
L	ALA111

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 H 309

Chain	Residue
H	ASP220
H	LYS221
H	LYS222

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 H 310

Chain	Residue
H	GLY118

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H 313

Chain	Residue
H	GLU16
H	THR17

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 H 315

Chain	Residue
H	ARG66
H	LYS83
H	GLU85

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 317

Chain	Residue
H	SER168
H	GLY169
H	HOH380
H	HOH410
L	LYS169
L	SO4319

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 318

Chain	Residue
H	LYS83
H	ASN84
H	GLU85
H	HOH373

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 H 320

Chain	Residue
H	GLN81
L	ASN210

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 H 321

Chain	Residue
H	GLU72
H	THR73
H	SER74

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 323

Chain	Residue
H	SER7
H	GLY8
H	LYS213
H	HOH394

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ANO H 501

Chain	Residue
H	ASN35
H	TRP50
H	GLY95
H	TRP100
L	ASN28
L	SER91

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR206-HIS212

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Region: {"description":"Framework-1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	15
Details	Region: {"description":"Complementarity-determining-1"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	14
Details	Region: {"description":"Framework-2"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Region: {"description":"Complementarity-determining-2"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	31
Details	Region: {"description":"Framework-3"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Region: {"description":"Complementarity-determining-3"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	9
Details	Region: {"description":"Framework-4"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	97
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	93
Details	Domain: {"description":"Ig-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	97
Details	Region: {"description":"CH1","evidences":[{"source":"PubMed","id":"15572068","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	20
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)