2O5W
Structure of the E. coli dihydroneopterin triphosphate pyrophosphohydrolase in complex with Sm+3 and pyrophosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0008828 | molecular_function | dATP diphosphatase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0008828 | molecular_function | dATP diphosphatase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0008828 | molecular_function | dATP diphosphatase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| C | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| C | 0046656 | biological_process | folic acid biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0008828 | molecular_function | dATP diphosphatase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| D | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| D | 0046656 | biological_process | folic acid biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 164 |
| Chain | Residue |
| A | LYS4 |
| A | LYS7 |
| A | ARG90 |
| A | PPV163 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 165 |
| Chain | Residue |
| A | ARG97 |
| A | ARG97 |
| A | TRP136 |
| A | TRP136 |
| A | HOH192 |
| A | GLU80 |
| A | PHE81 |
| A | PHE81 |
| A | GLU82 |
| A | GLU82 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 164 |
| Chain | Residue |
| B | LYS4 |
| B | LYS7 |
| B | ARG90 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 165 |
| Chain | Residue |
| B | PHE81 |
| B | GLU82 |
| B | ARG97 |
| B | TRP136 |
| C | PHE81 |
| C | GLU82 |
| C | ARG97 |
| C | TRP136 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SM A 170 |
| Chain | Residue |
| A | GLU56 |
| A | GLU59 |
| A | GLU117 |
| A | PPV163 |
| A | NA171 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SM B 170 |
| Chain | Residue |
| B | GLU56 |
| B | GLU59 |
| B | GLU60 |
| B | GLU117 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SM C 170 |
| Chain | Residue |
| C | GLU56 |
| C | GLU59 |
| C | GLU117 |
| C | PPV163 |
| C | NA171 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 171 |
| Chain | Residue |
| A | THR40 |
| A | GLU56 |
| A | GLU60 |
| A | PPV163 |
| A | SM170 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA C 171 |
| Chain | Residue |
| C | THR40 |
| C | GLU56 |
| C | GLU60 |
| C | GLU117 |
| C | PPV163 |
| C | SM170 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PPV A 163 |
| Chain | Residue |
| A | LYS7 |
| A | ARG29 |
| A | THR40 |
| A | GLY41 |
| A | SO4164 |
| A | SM170 |
| A | NA171 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PPV C 163 |
| Chain | Residue |
| C | LYS7 |
| C | ARG29 |
| C | THR40 |
| C | GLY41 |
| C | SM170 |
| C | NA171 |
| C | HOH183 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GsveegEtapqAAmREVkEEvT |
| Chain | Residue | Details |
| A | GLY41-THR62 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS7 | |
| B | GLU56 | |
| B | GLU60 | |
| B | GLU117 | |
| C | LYS7 | |
| C | ARG29 | |
| C | THR40 | |
| C | GLU56 | |
| C | GLU60 | |
| C | GLU117 | |
| D | LYS7 | |
| A | ARG29 | |
| D | ARG29 | |
| D | THR40 | |
| D | GLU56 | |
| D | GLU60 | |
| D | GLU117 | |
| A | THR40 | |
| A | GLU56 | |
| A | GLU60 | |
| A | GLU117 | |
| B | LYS7 | |
| B | ARG29 | |
| B | THR40 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE81 | |
| A | SER135 | |
| B | PHE81 | |
| B | SER135 | |
| C | PHE81 | |
| C | SER135 | |
| D | PHE81 | |
| D | SER135 |
