2O4G

Structure of TREX1 in complex with a nucleotide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0008408	molecular_function	3'-5' exonuclease activity
B	0003676	molecular_function	nucleic acid binding
B	0008408	molecular_function	3'-5' exonuclease activity
C	0003676	molecular_function	nucleic acid binding
C	0008408	molecular_function	3'-5' exonuclease activity
D	0003676	molecular_function	nucleic acid binding
D	0008408	molecular_function	3'-5' exonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 800

Chain	Residue
A	ASP18
A	LEU19
A	GLU20
A	ASP200
A	MG801
A	TMP1000

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 801

Chain	Residue
A	HOH1039
A	HOH1041
A	HOH1042
A	HOH1052
A	ASP18
A	MG800
A	TMP1000

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 800

Chain	Residue
B	ASP18
B	LEU19
B	GLU20
B	ASP200
B	MG801
B	TMP1000

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG B 801

Chain	Residue
B	ASP18
B	MG800
B	TMP1000
B	HOH1001
B	HOH1037
B	HOH1043
B	HOH1044

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 800

Chain	Residue
C	ASP18
C	GLU20
C	ASP200
C	MG801
C	TMP1000

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG C 801

Chain	Residue
C	ASP18
C	MG800
C	TMP1000
C	HOH1017
C	HOH1020
C	HOH1029
C	HOH1037

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 800

Chain	Residue
D	ASP18
D	LEU19
D	GLU20
D	ASP200
D	MG801
D	TMP1000

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG D 801

Chain	Residue
D	ASP18
D	MG800
D	TMP1000
D	HOH1011
D	HOH1015
D	HOH1044
D	HOH1045

---

site_id	AC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TMP A 1000

Chain	Residue
A	ASP18
A	LEU19
A	GLU20
A	ALA21
A	LEU24
A	ILE84
A	THR85
A	TYR129
A	HIS195
A	MG800
A	MG801
A	HOH1037
A	HOH1041
A	HOH1052

---

site_id	BC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TMP B 1000

Chain	Residue
B	ASP18
B	LEU19
B	GLU20
B	ALA21
B	LEU24
B	ILE84
B	THR85
B	TYR129
B	HIS195
B	ASP200
B	MG800
B	MG801
B	HOH1001
B	HOH1044
B	HOH1045

---

site_id	BC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TMP C 1000

Chain	Residue
C	ASP18
C	LEU19
C	GLU20
C	ALA21
C	ILE84
C	THR85
C	TYR129
C	HIS195
C	ASP200
C	MG800
C	MG801
C	HOH1020
C	HOH1037

---

site_id	BC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TMP D 1000

Chain	Residue
D	THR85
D	HIS195
D	MG800
D	MG801
D	HOH1044
D	HOH1045
D	HOH1055
D	ASP18
D	LEU19
D	GLU20
D	ALA21
D	LEU24
D	ILE84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:17355961

Chain	Residue	Details
A	HIS195
B	HIS195
C	HIS195
D	HIS195

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:17293595, ECO:0000269|PubMed:17355961, ECO:0000269|PubMed:18780819, ECO:0000269|PubMed:22071149

Chain	Residue	Details
A	ASP18
B	ASP18
B	GLU20
B	TYR129
B	ASP200
C	ASP18
C	GLU20
C	TYR129
C	ASP200
D	ASP18
D	GLU20
D	TYR129
D	ASP200
A	GLU20
A	TYR129
A	ASP200

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9NSU2

Chain	Residue	Details
A	SER78
A	SER167
B	SER78
B	SER167
C	SER78
C	SER167
D	SER78
D	SER167

---