2O4G
Structure of TREX1 in complex with a nucleotide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0008408 | molecular_function | 3'-5' exonuclease activity |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0008408 | molecular_function | 3'-5' exonuclease activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 800 |
| Chain | Residue |
| A | ASP18 |
| A | LEU19 |
| A | GLU20 |
| A | ASP200 |
| A | MG801 |
| A | TMP1000 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 801 |
| Chain | Residue |
| A | HOH1039 |
| A | HOH1041 |
| A | HOH1042 |
| A | HOH1052 |
| A | ASP18 |
| A | MG800 |
| A | TMP1000 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 800 |
| Chain | Residue |
| B | ASP18 |
| B | LEU19 |
| B | GLU20 |
| B | ASP200 |
| B | MG801 |
| B | TMP1000 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 801 |
| Chain | Residue |
| B | ASP18 |
| B | MG800 |
| B | TMP1000 |
| B | HOH1001 |
| B | HOH1037 |
| B | HOH1043 |
| B | HOH1044 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 800 |
| Chain | Residue |
| C | ASP18 |
| C | GLU20 |
| C | ASP200 |
| C | MG801 |
| C | TMP1000 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG C 801 |
| Chain | Residue |
| C | ASP18 |
| C | MG800 |
| C | TMP1000 |
| C | HOH1017 |
| C | HOH1020 |
| C | HOH1029 |
| C | HOH1037 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 800 |
| Chain | Residue |
| D | ASP18 |
| D | LEU19 |
| D | GLU20 |
| D | ASP200 |
| D | MG801 |
| D | TMP1000 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG D 801 |
| Chain | Residue |
| D | ASP18 |
| D | MG800 |
| D | TMP1000 |
| D | HOH1011 |
| D | HOH1015 |
| D | HOH1044 |
| D | HOH1045 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TMP A 1000 |
| Chain | Residue |
| A | ASP18 |
| A | LEU19 |
| A | GLU20 |
| A | ALA21 |
| A | LEU24 |
| A | ILE84 |
| A | THR85 |
| A | TYR129 |
| A | HIS195 |
| A | MG800 |
| A | MG801 |
| A | HOH1037 |
| A | HOH1041 |
| A | HOH1052 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TMP B 1000 |
| Chain | Residue |
| B | ASP18 |
| B | LEU19 |
| B | GLU20 |
| B | ALA21 |
| B | LEU24 |
| B | ILE84 |
| B | THR85 |
| B | TYR129 |
| B | HIS195 |
| B | ASP200 |
| B | MG800 |
| B | MG801 |
| B | HOH1001 |
| B | HOH1044 |
| B | HOH1045 |
| site_id | BC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE TMP C 1000 |
| Chain | Residue |
| C | ASP18 |
| C | LEU19 |
| C | GLU20 |
| C | ALA21 |
| C | ILE84 |
| C | THR85 |
| C | TYR129 |
| C | HIS195 |
| C | ASP200 |
| C | MG800 |
| C | MG801 |
| C | HOH1020 |
| C | HOH1037 |
| site_id | BC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE TMP D 1000 |
| Chain | Residue |
| D | THR85 |
| D | HIS195 |
| D | MG800 |
| D | MG801 |
| D | HOH1044 |
| D | HOH1045 |
| D | HOH1055 |
| D | ASP18 |
| D | LEU19 |
| D | GLU20 |
| D | ALA21 |
| D | LEU24 |
| D | ILE84 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"17355961","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17293595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780819","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22071149","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9NSU2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
