2O3R

Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating
B	0061809	molecular_function	NAD+ nucleosidase activity, cyclic ADP-ribose generating

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CXR A 301

Chain	Residue
A	TRP125
A	HOH310
A	HOH321
A	HOH338
A	HOH448
A	HOH453
A	HOH458
A	HOH475
A	ARG127
A	LYS129
A	GLU146
A	ASP155
A	ASP156
A	VAL185
A	TRP189
A	THR221

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CXR B 301

Chain	Residue
B	TRP125
B	LYS129
B	GLU146
B	ASP155
B	ASP156
B	VAL185
B	TRP189
B	THR221
B	HOH373
B	HOH417
B	HOH462

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"7961800","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1r16

Chain	Residue	Details
A	ASP226
A	GLU146

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1r16

Chain	Residue	Details
B	ASP226
B	GLU146

---