2O2C
Crystal structure of phosphoglucose isomerase from T. brucei containing glucose-6-phosphate in the active site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0020015 | cellular_component | glycosome |
| A | 0048029 | molecular_function | monosaccharide binding |
| A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| A | 0097367 | molecular_function | carbohydrate derivative binding |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0020015 | cellular_component | glycosome |
| B | 0048029 | molecular_function | monosaccharide binding |
| B | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| B | 0097367 | molecular_function | carbohydrate derivative binding |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
| C | 0004347 | molecular_function | glucose-6-phosphate isomerase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006094 | biological_process | gluconeogenesis |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0020015 | cellular_component | glycosome |
| C | 0048029 | molecular_function | monosaccharide binding |
| C | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| C | 0097367 | molecular_function | carbohydrate derivative binding |
| C | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE G6Q A 5001 |
| Chain | Residue |
| A | ILE205 |
| A | ARG326 |
| A | GLN407 |
| A | GLU411 |
| A | HIS442 |
| A | GLN564 |
| A | HOH7018 |
| A | HOH7128 |
| A | HOH7164 |
| A | HOH7337 |
| A | HOH7340 |
| A | GLY206 |
| A | HOH7363 |
| A | GLY207 |
| A | SER208 |
| A | SER258 |
| A | LYS259 |
| A | THR260 |
| A | THR263 |
| A | GLY325 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE G6Q B 5002 |
| Chain | Residue |
| B | ILE205 |
| B | GLY206 |
| B | GLY207 |
| B | SER208 |
| B | SER258 |
| B | LYS259 |
| B | THR260 |
| B | THR263 |
| B | GLY325 |
| B | ARG326 |
| B | GLN407 |
| B | GLU411 |
| B | GLN564 |
| B | HOH7012 |
| B | HOH7112 |
| B | HOH7288 |
| B | HOH7318 |
| B | HOH7325 |
| B | HOH7362 |
| B | HOH7373 |
| B | HOH7447 |
| C | HIS442 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE G6Q C 5003 |
| Chain | Residue |
| B | HIS442 |
| C | ILE205 |
| C | GLY207 |
| C | SER208 |
| C | SER258 |
| C | LYS259 |
| C | THR260 |
| C | THR263 |
| C | GLY325 |
| C | ARG326 |
| C | GLN407 |
| C | GLU411 |
| C | GLN564 |
| C | HOH7014 |
| C | HOH7105 |
| C | HOH7243 |
| C | HOH7257 |
| C | HOH7261 |
| C | HOH7273 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 7001 |
| Chain | Residue |
| A | THR77 |
| A | ASP78 |
| A | ARG81 |
| A | TYR85 |
| A | ASN109 |
| A | ASP110 |
| A | HOH7213 |
| A | HOH7278 |
| B | ASN588 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 7005 |
| Chain | Residue |
| A | LEU278 |
| A | GLU288 |
| A | LYS289 |
| A | GLY290 |
| A | SER291 |
| A | VAL292 |
| A | HOH7242 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 7002 |
| Chain | Residue |
| B | HIS74 |
| B | THR77 |
| B | ASP78 |
| B | ARG81 |
| B | ASP110 |
| B | HOH7383 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 7004 |
| Chain | Residue |
| B | GLU188 |
| B | TRP189 |
| B | LYS190 |
| B | LYS294 |
| B | HOH7264 |
| B | HOH7303 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 7006 |
| Chain | Residue |
| B | LYS220 |
| B | GLN396 |
| B | TYR397 |
| B | TRP399 |
| B | HOH7146 |
| B | HOH7241 |
| B | HOH7403 |
| C | HIS239 |
| C | GLU242 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 7003 |
| Chain | Residue |
| C | ASP78 |
| C | ARG81 |
| C | TYR85 |
| C | ASN109 |
| C | ASP110 |
| C | HIS74 |
Functional Information from PROSITE/UniProt
| site_id | PS00174 |
| Number of Residues | 18 |
| Details | P_GLUCOSE_ISOMERASE_2 Phosphoglucose isomerase signature 2. GaIWgidsYDQwGVElgK |
| Chain | Residue | Details |
| A | GLY554-LYS571 |
| site_id | PS00765 |
| Number of Residues | 14 |
| Details | P_GLUCOSE_ISOMERASE_1 Phosphoglucose isomerase signature 1. DwVGGRYSMwSAIG |
| Chain | Residue | Details |
| A | ASP321-GLY334 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| A | GLY325 | |
| A | LYS259 | |
| A | ARG326 | |
| A | GLU411 | |
| A | GLU265 | |
| A | LYS571 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| B | GLY325 | |
| B | LYS259 | |
| B | ARG326 | |
| B | GLU411 | |
| B | GLU265 | |
| B | LYS571 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| C | GLY325 | |
| C | LYS259 | |
| C | ARG326 | |
| C | GLU411 | |
| C | GLU265 | |
| C | LYS571 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| A | HIS442 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| B | HIS442 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqr |
| Chain | Residue | Details |
| C | HIS442 |
