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2O25

Ubiquitin-Conjugating Enzyme E2-25 kDa Complexed With SUMO-1-Conjugating Enzyme UBC9

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000209biological_processprotein polyubiquitination
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
A0010994biological_processfree ubiquitin chain polymerization
A0016567biological_processprotein ubiquitination
A0016740molecular_functiontransferase activity
A0031625molecular_functionubiquitin protein ligase binding
A0032433cellular_componentfilopodium tip
A0032434biological_processregulation of proteasomal ubiquitin-dependent protein catabolic process
A0034450molecular_functionubiquitin-ubiquitin ligase activity
A0035458biological_processcellular response to interferon-beta
A0060337biological_processtype I interferon-mediated signaling pathway
A0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
A0061631molecular_functionubiquitin conjugating enzyme activity
A0070936biological_processprotein K48-linked ubiquitination
A1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
B0000166molecular_functionnucleotide binding
B0000209biological_processprotein polyubiquitination
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006511biological_processubiquitin-dependent protein catabolic process
B0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
B0010994biological_processfree ubiquitin chain polymerization
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0031625molecular_functionubiquitin protein ligase binding
B0032433cellular_componentfilopodium tip
B0032434biological_processregulation of proteasomal ubiquitin-dependent protein catabolic process
B0034450molecular_functionubiquitin-ubiquitin ligase activity
B0035458biological_processcellular response to interferon-beta
B0060337biological_processtype I interferon-mediated signaling pathway
B0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
B0061631molecular_functionubiquitin conjugating enzyme activity
B0070936biological_processprotein K48-linked ubiquitination
B1903265biological_processpositive regulation of tumor necrosis factor-mediated signaling pathway
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000166molecular_functionnucleotide binding
C0000795cellular_componentsynaptonemal complex
C0001221molecular_functiontranscription coregulator binding
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005643cellular_componentnuclear pore
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006511biological_processubiquitin-dependent protein catabolic process
C0007059biological_processchromosome segregation
C0007084biological_processmitotic nuclear membrane reassembly
C0008134molecular_functiontranscription factor binding
C0016604cellular_componentnuclear body
C0016605cellular_componentPML body
C0016740molecular_functiontransferase activity
C0016925biological_processprotein sumoylation
C0019789molecular_functionSUMO transferase activity
C0019899molecular_functionenzyme binding
C0030335biological_processpositive regulation of cell migration
C0036211biological_processprotein modification process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043398molecular_functionHLH domain binding
C0044388molecular_functionsmall protein activating enzyme binding
C0045892biological_processnegative regulation of DNA-templated transcription
C0048471cellular_componentperinuclear region of cytoplasm
C0050804biological_processmodulation of chemical synaptic transmission
C0051168biological_processnuclear export
C0051301biological_processcell division
C0061656molecular_functionSUMO conjugating enzyme activity
C0071535molecular_functionRING-like zinc finger domain binding
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098978cellular_componentglutamatergic synapse
C0099523cellular_componentpresynaptic cytosol
C0099524cellular_componentpostsynaptic cytosol
C0106068cellular_componentSUMO ligase complex
C1990234cellular_componenttransferase complex
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000166molecular_functionnucleotide binding
D0000795cellular_componentsynaptonemal complex
D0001221molecular_functiontranscription coregulator binding
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005635cellular_componentnuclear envelope
D0005643cellular_componentnuclear pore
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006511biological_processubiquitin-dependent protein catabolic process
D0007059biological_processchromosome segregation
D0007084biological_processmitotic nuclear membrane reassembly
D0008134molecular_functiontranscription factor binding
D0016604cellular_componentnuclear body
D0016605cellular_componentPML body
D0016740molecular_functiontransferase activity
D0016925biological_processprotein sumoylation
D0019789molecular_functionSUMO transferase activity
D0019899molecular_functionenzyme binding
D0030335biological_processpositive regulation of cell migration
D0036211biological_processprotein modification process
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043398molecular_functionHLH domain binding
D0044388molecular_functionsmall protein activating enzyme binding
D0045892biological_processnegative regulation of DNA-templated transcription
D0048471cellular_componentperinuclear region of cytoplasm
D0050804biological_processmodulation of chemical synaptic transmission
D0051168biological_processnuclear export
D0051301biological_processcell division
D0061656molecular_functionSUMO conjugating enzyme activity
D0071535molecular_functionRING-like zinc finger domain binding
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098978cellular_componentglutamatergic synapse
D0099523cellular_componentpresynaptic cytosol
D0099524cellular_componentpostsynaptic cytosol
D0106068cellular_componentSUMO ligase complex
D1990234cellular_componenttransferase complex
Functional Information from PROSITE/UniProt
site_idPS00183
Number of Residues16
DetailsUBC_1 Ubiquitin-conjugating (UBC) active site signature. FHPNVyps.GtVCLsiL
ChainResidueDetails
CPHE82-LEU97
ATRP80-LEU96

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Glycyl thioester intermediate
ChainResidueDetails
CCYS93
DCYS93

site_idSWS_FT_FI2
Number of Residues6
DetailsSITE: Interaction with RANBP2
ChainResidueDetails
CILE4
CVAL25
CLEU57
DILE4
DVAL25
DLEU57

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Substrate binding
ChainResidueDetails
CASP100
DASP100

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
CSER2
DSER2

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS65
DLYS65
BGLU15

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:22509284, ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER71
DSER71

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
CLYS18
DLYS18

site_idSWS_FT_FI8
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
CLYS101
DLYS101

site_idSWS_FT_FI9
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
CLYS48
DLYS48

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
CLYS49
DLYS49

237735

PDB entries from 2025-06-18

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