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2NZT

Crystal structure of human hexokinase II

Functional Information from GO Data
ChainGOidnamespacecontents
A0001666biological_processresponse to hypoxia
A0001678biological_processintracellular glucose homeostasis
A0002931biological_processresponse to ischemia
A0004340molecular_functionglucokinase activity
A0004396molecular_functionhexokinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005536molecular_functionD-glucose binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005975biological_processcarbohydrate metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006006biological_processglucose metabolic process
A0006096biological_processglycolytic process
A0007595biological_processlactation
A0008637biological_processapoptotic mitochondrial changes
A0008865molecular_functionfructokinase activity
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016529cellular_componentsarcoplasmic reticulum
A0016773molecular_functionphosphotransferase activity, alcohol group as acceptor
A0019318biological_processhexose metabolic process
A0035795biological_processnegative regulation of mitochondrial membrane permeability
A0043231cellular_componentintracellular membrane-bounded organelle
A0045766biological_processpositive regulation of angiogenesis
A0046324biological_processregulation of glucose import
A0046835biological_processcarbohydrate phosphorylation
A0051156biological_processglucose 6-phosphate metabolic process
A0061621biological_processcanonical glycolysis
A0072655biological_processestablishment of protein localization to mitochondrion
A0072656biological_processmaintenance of protein location in mitochondrion
A1901135biological_processcarbohydrate derivative metabolic process
A1904925biological_processpositive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
A1990830biological_processcellular response to leukemia inhibitory factor
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
B0001666biological_processresponse to hypoxia
B0001678biological_processintracellular glucose homeostasis
B0002931biological_processresponse to ischemia
B0004340molecular_functionglucokinase activity
B0004396molecular_functionhexokinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005536molecular_functionD-glucose binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005975biological_processcarbohydrate metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006006biological_processglucose metabolic process
B0006096biological_processglycolytic process
B0007595biological_processlactation
B0008637biological_processapoptotic mitochondrial changes
B0008865molecular_functionfructokinase activity
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016529cellular_componentsarcoplasmic reticulum
B0016773molecular_functionphosphotransferase activity, alcohol group as acceptor
B0019318biological_processhexose metabolic process
B0035795biological_processnegative regulation of mitochondrial membrane permeability
B0043231cellular_componentintracellular membrane-bounded organelle
B0045766biological_processpositive regulation of angiogenesis
B0046324biological_processregulation of glucose import
B0046835biological_processcarbohydrate phosphorylation
B0051156biological_processglucose 6-phosphate metabolic process
B0061621biological_processcanonical glycolysis
B0072655biological_processestablishment of protein localization to mitochondrion
B0072656biological_processmaintenance of protein location in mitochondrion
B1901135biological_processcarbohydrate derivative metabolic process
B1904925biological_processpositive regulation of autophagy of mitochondrion in response to mitochondrial depolarization
B1990830biological_processcellular response to leukemia inhibitory factor
B2000378biological_processnegative regulation of reactive oxygen species metabolic process
Functional Information from PROSITE/UniProt
site_idPS00378
Number of Residues26
DetailsHEXOKINASE_1 Hexokinase domain signature. LGFTFSFPchqtkLDesfLvsWTKgF
ChainResidueDetails
ALEU150-PHE175
ALEU598-PHE623

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P19367
ChainResidueDetails
AARG30
BTHR863
ALYS425
AGLY747
ATHR784
ATHR863
BARG30
BLYS425
BGLY747
BTHR784

site_idSWS_FT_FI2
Number of Residues34
DetailsBINDING: BINDING => ECO:0000269|PubMed:29298880, ECO:0007744|PDB:2NZT
ChainResidueDetails
AASP84
AASP413
ASER449
ASER603
ATHR620
AASN656
ASER682
AGLU708
AGLN739
BASP84
BSER155
ASER155
BTHR172
BASN208
BASP209
BTHR232
BASN235
BGLU260
BGLN291
BASP413
BSER449
BSER603
ATHR172
BTHR620
BASN656
BSER682
BGLU708
BGLN739
AASN208
AASP209
ATHR232
AASN235
AGLU260
AGLN291

site_idSWS_FT_FI3
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:26985301, ECO:0000269|PubMed:29298880, ECO:0007744|PDB:2NZT, ECO:0007744|PDB:5HG1
ChainResidueDetails
AASP532
BSER897
AASP657
ATHR680
AASP861
ASER897
BASP532
BASP657
BTHR680
BASP861

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ig8
ChainResidueDetails
ASER603
AASP657
ALYS618

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ig8
ChainResidueDetails
BSER603
BASP657
BLYS618

224572

PDB entries from 2024-09-04

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