2NZ9
Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody AR2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0008320 | molecular_function | protein transmembrane transporter activity |
A | 0016020 | cellular_component | membrane |
A | 0020002 | cellular_component | host cell plasma membrane |
A | 0030430 | cellular_component | host cell cytoplasm |
A | 0035821 | biological_process | modulation of process of another organism |
A | 0044161 | cellular_component | host cell cytoplasmic vesicle |
A | 0044164 | cellular_component | host cell cytosol |
A | 0044221 | cellular_component | host cell synapse |
A | 0044231 | cellular_component | host cell presynaptic membrane |
A | 0046872 | molecular_function | metal ion binding |
A | 0071806 | biological_process | protein transmembrane transport |
A | 0090729 | molecular_function | toxin activity |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0005576 | cellular_component | extracellular region |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0008320 | molecular_function | protein transmembrane transporter activity |
B | 0016020 | cellular_component | membrane |
B | 0020002 | cellular_component | host cell plasma membrane |
B | 0030430 | cellular_component | host cell cytoplasm |
B | 0035821 | biological_process | modulation of process of another organism |
B | 0044161 | cellular_component | host cell cytoplasmic vesicle |
B | 0044164 | cellular_component | host cell cytosol |
B | 0044221 | cellular_component | host cell synapse |
B | 0044231 | cellular_component | host cell presynaptic membrane |
B | 0046872 | molecular_function | metal ion binding |
B | 0071806 | biological_process | protein transmembrane transport |
B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ZN A 1 |
Chain | Residue |
A | HIS223 |
A | HIS227 |
A | GLU262 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ZN B 1297 |
Chain | Residue |
B | HIS223 |
B | HIS227 |
B | GLU262 |
site_id | AC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CA A 1297 |
Chain | Residue |
A | GLU347 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CA B 1298 |
Chain | Residue |
B | GLU279 |
B | LYS711 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLAHELIHAG |
Chain | Residue | Details |
A | THR220-GLY229 |
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
Chain | Residue | Details |
D | TYR199-HIS205 | |
C | TYR196-HIS202 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 80 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
A | ALA628-TYR648 | |
A | ILE657-GLY677 | |
B | ALA628-TYR648 | |
B | ILE657-GLY677 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095 |
Chain | Residue | Details |
A | LEU225 | |
B | LEU225 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:17173035, ECO:0000305|PubMed:9783750, ECO:0007744|PDB:2NYY, ECO:0007744|PDB:2NZ9, ECO:0007744|PDB:3BTA, ECO:0007744|PDB:3QIX, ECO:0007744|PDB:3QIY, ECO:0007744|PDB:3QIZ, ECO:0007744|PDB:3QJ0 |
Chain | Residue | Details |
A | GLU224 | |
A | ALA228 | |
B | GLU224 | |
B | ALA228 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:17173035, ECO:0007744|PDB:2NYY, ECO:0007744|PDB:2NZ9, ECO:0007744|PDB:3BTA, ECO:0007744|PDB:3QIX, ECO:0007744|PDB:3QIY, ECO:0007744|PDB:3QIZ, ECO:0007744|PDB:3QJ0 |
Chain | Residue | Details |
A | LEU263 | |
B | LEU263 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18704164, ECO:0000269|PubMed:27958736, ECO:0007744|PDB:2VU9, ECO:0007744|PDB:5TPB, ECO:0007744|PDB:5TPC |
Chain | Residue | Details |
A | ASP1118 | |
B | ASP1118 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18704164, ECO:0000269|PubMed:27958736, ECO:0000305|PubMed:14731268, ECO:0007744|PDB:2VU9, ECO:0007744|PDB:5TPB, ECO:0007744|PDB:5TPC |
Chain | Residue | Details |
A | LYS1204 | |
B | LYS1204 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:11827515 |
Chain | Residue | Details |
A | LYS364 | |
A | LEU367 | |
B | LYS364 | |
B | LEU367 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1i1e |
Chain | Residue | Details |
A | GLU262 | |
A | TYR366 | |
A | ARG363 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1i1e |
Chain | Residue | Details |
B | GLU262 | |
B | TYR366 | |
B | ARG363 |