2NZ0
Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0008076 | cellular_component | voltage-gated potassium channel complex |
| B | 0051260 | biological_process | protein homooligomerization |
| C | 0005509 | molecular_function | calcium ion binding |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0008076 | cellular_component | voltage-gated potassium channel complex |
| D | 0051260 | biological_process | protein homooligomerization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 301 |
| Chain | Residue |
| A | ASP135 |
| A | ASN137 |
| A | TYR141 |
| A | GLU146 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 302 |
| Chain | Residue |
| A | ASN185 |
| A | ASP187 |
| A | ILE189 |
| A | GLU194 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | CYS131 |
| B | CYS132 |
| D | CYS110 |
| B | HIS104 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 301 |
| Chain | Residue |
| C | ASP135 |
| C | ASN137 |
| C | TYR141 |
| C | ASN143 |
| C | GLU146 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 302 |
| Chain | Residue |
| C | ASN185 |
| C | ASP187 |
| C | ILE189 |
| C | GLU194 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 301 |
| Chain | Residue |
| B | CYS110 |
| D | HIS104 |
| D | CYS131 |
| D | CYS132 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DINKDGYINkeEM |
| Chain | Residue | Details |
| A | ASP135-MET147 | |
| A | ASP183-PHE195 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 26 |
| Details | Region: {"description":"Interaction with KCND2","evidences":[{"source":"UniProtKB","id":"Q8R426","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17057713","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 30 |
| Details | Region: {"description":"Interaction with KCNIP1 and KCNIP2","evidences":[{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34997220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | Region: {"description":"Interaction with KCNIP1","evidences":[{"source":"PubMed","id":"17187064","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"PDB","id":"1S1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NZ0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"in chain D","evidences":[{"source":"PDB","id":"1S1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NZ0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
