Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| X | 0016491 | molecular_function | oxidoreductase activity |
| X | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| X | 0045454 | biological_process | cell redox homeostasis |
| X | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD X 489 |
| Chain | Residue |
| X | GLY16 |
| X | CYS57 |
| X | VAL60 |
| X | GLY61 |
| X | CYS62 |
| X | LYS65 |
| X | GLY128 |
| X | LEU129 |
| X | GLY130 |
| X | ALA157 |
| X | VAL158 |
| X | GLY17 |
| X | GLY159 |
| X | TYR197 |
| X | ILE198 |
| X | ARG287 |
| X | LEU290 |
| X | GLY325 |
| X | ASP326 |
| X | GLU333 |
| X | LEU334 |
| X | THR335 |
| X | GLY18 |
| X | PRO336 |
| X | HIS464 |
| X | HOH492 |
| X | HOH498 |
| X | HOH514 |
| X | HOH517 |
| X | HOH523 |
| X | HOH566 |
| X | SER19 |
| X | ALA20 |
| X | ASP39 |
| X | PHE40 |
| X | GLY55 |
| X | THR56 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE NAP X 490 |
| Chain | Residue |
| X | GLY194 |
| X | ALA195 |
| X | GLY196 |
| X | ARG218 |
| X | SER219 |
| X | ARG223 |
| X | ALA284 |
| X | ILE285 |
| X | GLY286 |
| X | ARG287 |
| X | HOH535 |
| X | HOH570 |
| X | HOH610 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
| Chain | Residue | Details |
| X | GLY54-PRO64 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17385893","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17385893","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| X | CYS62 | |
| X | CYS57 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| X | GLU469 | |
| X | HIS464 | |
