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2NVH

Determination of Solvent Content in Cavities in Interleukin-1 Using Experimentally-Phased Electron Density

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005615cellular_componentextracellular space
A0006954biological_processinflammatory response
A0006955biological_processimmune response
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 160
ChainResidue
AALA1
APRO2
AVAL3
ALYS92
ALYS93
AHOH276

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 161
ChainResidue
AGLU96
AARG98
AHOH326

Functional Information from PROSITE/UniProt
site_idPS00253
Number of Residues21
DetailsINTERLEUKIN_1 Interleukin-1 signature. FeSAqfPnwYISTsqaenmpV
ChainResidueDetails
APHE112-VAL132

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Involved in receptor binding
ChainResidueDetails
AARG4

site_idSWS_FT_FI2
Number of Residues5
DetailsSITE: Important for interaction with integrin => ECO:0000269|PubMed:29030430
ChainResidueDetails
ALYS55
ALYS63
ALYS65
ALYS74
ALYS88

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PDB entries from 2024-11-06

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