2NU9
C123aT Mutant of E. coli Succinyl-CoA Synthetase Orthorhombic Crystal Form
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
A | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006099 | biological_process | tricarboxylic acid cycle |
A | 0009361 | cellular_component | succinate-CoA ligase complex (ADP-forming) |
A | 0016874 | molecular_function | ligase activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
B | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006099 | biological_process | tricarboxylic acid cycle |
B | 0006104 | biological_process | succinyl-CoA metabolic process |
B | 0009361 | cellular_component | succinate-CoA ligase complex (ADP-forming) |
B | 0016874 | molecular_function | ligase activity |
B | 0042709 | cellular_component | succinate-CoA ligase complex |
B | 0046872 | molecular_function | metal ion binding |
D | 0000166 | molecular_function | nucleotide binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
D | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
D | 0005515 | molecular_function | protein binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006099 | biological_process | tricarboxylic acid cycle |
D | 0009361 | cellular_component | succinate-CoA ligase complex (ADP-forming) |
D | 0016874 | molecular_function | ligase activity |
E | 0000287 | molecular_function | magnesium ion binding |
E | 0003824 | molecular_function | catalytic activity |
E | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
E | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
E | 0005515 | molecular_function | protein binding |
E | 0005524 | molecular_function | ATP binding |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006099 | biological_process | tricarboxylic acid cycle |
E | 0006104 | biological_process | succinyl-CoA metabolic process |
E | 0009361 | cellular_component | succinate-CoA ligase complex (ADP-forming) |
E | 0016874 | molecular_function | ligase activity |
E | 0042709 | cellular_component | succinate-CoA ligase complex |
E | 0046872 | molecular_function | metal ion binding |
F | 0000166 | molecular_function | nucleotide binding |
F | 0003824 | molecular_function | catalytic activity |
F | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
F | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
F | 0005515 | molecular_function | protein binding |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006099 | biological_process | tricarboxylic acid cycle |
F | 0009361 | cellular_component | succinate-CoA ligase complex (ADP-forming) |
F | 0016874 | molecular_function | ligase activity |
G | 0000287 | molecular_function | magnesium ion binding |
G | 0003824 | molecular_function | catalytic activity |
G | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
G | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
G | 0005515 | molecular_function | protein binding |
G | 0005524 | molecular_function | ATP binding |
G | 0005737 | cellular_component | cytoplasm |
G | 0005829 | cellular_component | cytosol |
G | 0006099 | biological_process | tricarboxylic acid cycle |
G | 0006104 | biological_process | succinyl-CoA metabolic process |
G | 0009361 | cellular_component | succinate-CoA ligase complex (ADP-forming) |
G | 0016874 | molecular_function | ligase activity |
G | 0042709 | cellular_component | succinate-CoA ligase complex |
G | 0046872 | molecular_function | metal ion binding |
H | 0000166 | molecular_function | nucleotide binding |
H | 0003824 | molecular_function | catalytic activity |
H | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
H | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
H | 0005515 | molecular_function | protein binding |
H | 0005737 | cellular_component | cytoplasm |
H | 0005829 | cellular_component | cytosol |
H | 0006099 | biological_process | tricarboxylic acid cycle |
H | 0009361 | cellular_component | succinate-CoA ligase complex (ADP-forming) |
H | 0016874 | molecular_function | ligase activity |
I | 0000287 | molecular_function | magnesium ion binding |
I | 0003824 | molecular_function | catalytic activity |
I | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
I | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
I | 0005515 | molecular_function | protein binding |
I | 0005524 | molecular_function | ATP binding |
I | 0005737 | cellular_component | cytoplasm |
I | 0005829 | cellular_component | cytosol |
I | 0006099 | biological_process | tricarboxylic acid cycle |
I | 0006104 | biological_process | succinyl-CoA metabolic process |
I | 0009361 | cellular_component | succinate-CoA ligase complex (ADP-forming) |
I | 0016874 | molecular_function | ligase activity |
I | 0042709 | cellular_component | succinate-CoA ligase complex |
I | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 389 |
Chain | Residue |
B | GLY53 |
B | ARG54 |
B | GLY55 |
B | ASP213 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 390 |
Chain | Residue |
A | ARG243 |
B | MET1 |
B | GLY220 |
B | ARG233 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 E 389 |
Chain | Residue |
E | GLY53 |
E | ARG54 |
E | GLY55 |
E | ASP213 |
E | GLY52 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 E 390 |
Chain | Residue |
D | ARG243 |
E | MET1 |
E | GLY220 |
E | ARG233 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 G 389 |
Chain | Residue |
G | GLY52 |
G | GLY53 |
G | ARG54 |
G | GLY55 |
G | ASP213 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 G 390 |
Chain | Residue |
F | ARG243 |
G | MET1 |
G | GLY220 |
G | ARG233 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 I 389 |
Chain | Residue |
I | GLY52 |
I | GLY53 |
I | ARG54 |
I | GLY55 |
I | ASP213 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 I 390 |
Chain | Residue |
H | ARG243 |
I | MET1 |
I | GLY220 |
I | ARG233 |
site_id | AC9 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE COA A 300 |
Chain | Residue |
A | THR16 |
A | GLY17 |
A | SER18 |
A | GLN19 |
A | VAL38 |
A | THR39 |
A | PRO40 |
A | LYS42 |
A | TYR71 |
A | VAL72 |
A | PRO73 |
A | ILE95 |
A | THR96 |
A | GLU97 |
A | ASN122 |
A | THR123 |
A | PRO124 |
A | ILE136 |
A | NEP246 |
E | GLU33 |
E | SER36 |
E | LYS66 |
site_id | BC1 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE COA D 301 |
Chain | Residue |
B | GLU33 |
B | SER36 |
B | LYS66 |
D | GLY14 |
D | THR16 |
D | GLY17 |
D | SER18 |
D | GLN19 |
D | THR39 |
D | LYS42 |
D | TYR71 |
D | VAL72 |
D | PRO73 |
D | ILE95 |
D | THR96 |
D | GLU97 |
D | THR123 |
D | PRO124 |
D | ILE136 |
I | ARG161 |
site_id | BC2 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE COA F 400 |
Chain | Residue |
I | GLU33 |
I | SER36 |
I | LYS66 |
B | ARG161 |
F | GLY14 |
F | THR16 |
F | GLY17 |
F | SER18 |
F | GLN19 |
F | VAL38 |
F | THR39 |
F | PRO40 |
F | LYS42 |
F | TYR71 |
F | VAL72 |
F | PRO73 |
F | SER80 |
F | ILE95 |
F | THR96 |
F | GLU97 |
F | ASN122 |
F | THR123 |
F | ILE136 |
F | NEP246 |
I | ARG29 |
site_id | BC3 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE COA H 401 |
Chain | Residue |
G | ARG29 |
G | GLU33 |
G | SER36 |
G | LYS66 |
H | THR16 |
H | GLY17 |
H | SER18 |
H | GLN19 |
H | THR39 |
H | PRO40 |
H | LYS42 |
H | TYR71 |
H | VAL72 |
H | PRO73 |
H | ILE95 |
H | THR96 |
H | GLU97 |
H | ASN122 |
H | THR123 |
H | PRO124 |
Functional Information from PROSITE/UniProt
site_id | PS00399 |
Number of Residues | 14 |
Details | SUCCINYL_COA_LIG_2 ATP-citrate lyase / succinyl-CoA ligases family active site. GvtApkgk...RMGHAG |
Chain | Residue | Details |
A | GLY235-GLY248 |
site_id | PS01216 |
Number of Residues | 30 |
Details | SUCCINYL_COA_LIG_1 ATP-citrate lyase / succinyl-CoA ligases family signature 1. SRSGTLTyEavkqttdygfGqstcVGIGGD |
Chain | Residue | Details |
A | SER151-ASP180 |
site_id | PS01217 |
Number of Residues | 26 |
Details | SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GnIgcMvNGAGLAmgtmDiVklhgGE |
Chain | Residue | Details |
B | GLY257-GLU282 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 28 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00558, ECO:0000269|PubMed:10625475 |
Chain | Residue | Details |
B | LYS46 | |
E | GLU99 | |
E | THR102 | |
E | GLU107 | |
E | ASN199 | |
E | ASP213 | |
G | LYS46 | |
G | GLY53 | |
G | GLU99 | |
G | THR102 | |
G | GLU107 | |
B | GLY53 | |
G | ASN199 | |
G | ASP213 | |
I | LYS46 | |
I | GLY53 | |
I | GLU99 | |
I | THR102 | |
I | GLU107 | |
I | ASN199 | |
I | ASP213 | |
B | GLU99 | |
B | THR102 | |
B | GLU107 | |
B | ASN199 | |
B | ASP213 | |
E | LYS46 | |
E | GLY53 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00558 |
Chain | Residue | Details |
B | ASN264 | |
H | GLY17 | |
H | GLY43 | |
H | THR96 | |
B | GLY321 | |
E | ASN264 | |
E | GLY321 | |
G | ASN264 | |
G | GLY321 | |
I | ASN264 | |
I | GLY321 | |
F | THR96 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01988 |
Chain | Residue | Details |
A | GLU159 | |
D | GLU159 | |
F | GLU159 | |
H | GLU159 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1cqj |
Chain | Residue | Details |
A | GLU208 | |
B | TYR109 | |
B | GLU197 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1cqj |
Chain | Residue | Details |
D | GLU208 | |
E | TYR109 | |
E | GLU197 |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1cqj |
Chain | Residue | Details |
F | GLU208 | |
G | TYR109 | |
G | GLU197 |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1cqj |
Chain | Residue | Details |
H | GLU208 | |
I | TYR109 | |
I | GLU197 |
site_id | MCSA1 |
Number of Residues | 2 |
Details | M-CSA 476 |
Chain | Residue | Details |
B | TYR109 | electrostatic stabiliser, steric role |
B | GLU197 | electrostatic stabiliser, modifies pKa |
site_id | MCSA2 |
Number of Residues | 2 |
Details | M-CSA 476 |
Chain | Residue | Details |
E | TYR109 | electrostatic stabiliser, steric role |
E | GLU197 | electrostatic stabiliser, modifies pKa |
site_id | MCSA3 |
Number of Residues | 2 |
Details | M-CSA 476 |
Chain | Residue | Details |
G | TYR109 | electrostatic stabiliser, steric role |
G | GLU197 | electrostatic stabiliser, modifies pKa |
site_id | MCSA4 |
Number of Residues | 2 |
Details | M-CSA 476 |
Chain | Residue | Details |
I | TYR109 | electrostatic stabiliser, steric role |
I | GLU197 | electrostatic stabiliser, modifies pKa |