2NRF

Crystal Structure of GlpG, a Rhomboid family intramembrane protease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0016020	cellular_component	membrane
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	TRANSMEM: Helical; Name=1 => ECO:0000305

Chain	Residue	Details
A	GLY94-LEU114
B	GLY94-LEU114

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	TOPO_DOM: Periplasmic => ECO:0000305

Chain	Residue	Details
A	GLY115-HIS141
A	GLN190-LYS191
A	GLY246-MET249
B	GLY115-HIS141
B	GLN190-LYS191
B	GLY246-MET249

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	TRANSMEM: Helical; Name=2 => ECO:0000305

Chain	Residue	Details
A	ALA142-GLY162
B	ALA142-GLY162

---

site_id	SWS_FT_FI4
Number of Residues	28
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	GLY163-ARG168
A	LEU213-GLY222
B	GLY163-ARG168
B	LEU213-GLY222

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	TRANSMEM: Helical; Name=3 => ECO:0000305

Chain	Residue	Details
A	LEU169-GLN189
B	LEU169-GLN189

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	TRANSMEM: Helical; Name=4 => ECO:0000305

Chain	Residue	Details
A	PHE192-TRP212
B	PHE192-TRP212

---

site_id	SWS_FT_FI7
Number of Residues	44
Details	TRANSMEM: Helical; Name=5 => ECO:0000305

Chain	Residue	Details
A	ILE223-PHE245
B	ILE223-PHE245

---

site_id	SWS_FT_FI8
Number of Residues	44
Details	TRANSMEM: Helical; Name=6 => ECO:0000305

Chain	Residue	Details
A	ALA250-ALA272
B	ALA250-ALA272

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:17051161, ECO:0000305|PubMed:17099694, ECO:0000305|PubMed:17190827, ECO:0000305|PubMed:17277078

Chain	Residue	Details
A	SER201
B	SER201

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:17051161, ECO:0000305|PubMed:17099694, ECO:0000305|PubMed:17190827, ECO:0000305|PubMed:17277078

Chain	Residue	Details
A	HIS254
B	HIS254

---